| 梁琛 李伟 邵晓平 王意雯 唐惠.硫辛酸对卵巢切除小鼠学习记忆的影响[J].,2016,16(29):5636-5639 |
| 硫辛酸对卵巢切除小鼠学习记忆的影响 |
| Effect of Lipoic Acid on Learning and Memory Capacity of Ovariectomized Mice |
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| DOI： |
| 中文关键词: 卵巢切除 硫辛酸 学习记忆 eNOS |
| 英文关键词: Ovariectomized Lipoic acid Learning and memory eNOS |
| 基金项目:江苏省自然科学基金项目(BK20150218) |
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| 中文摘要: |
| 目的：探讨硫辛酸（Lipoic acid，LA）对卵巢切除（ovariectomized，OVX）小鼠学习记忆的影响。方法：2月龄雌性昆明小鼠随机
分为4 组：假手术（Sham）组、OVX组、OVX+LA 组、OVX+LA+ 左旋硝基精氨酸甲酯（L-NAME）组。建立卵巢切除模型并给药，
Morris水迷宫检测各组小鼠学习记忆能力。结果：前4 天定位巡航实验中，OVX组与Sham组相比，逃避潜伏期明显延长（P<0.
05），第5 天撤除平台后，OVX组在目的象限游泳距离及时间百分比较Sham 组明显缩短（P<0.05）；OVX+LA 组与OVX 组相比，
逃避潜伏期明显缩短（P<0.05），撤除平台后，在目的象限游泳距离及时间百分比明显延长（P<0.05）；OVX+LA+L-NAME 组与
Sham 组相比，逃避潜伏期明显延长（P<0.05），撤除平台后，在目的象限游泳距离及时间百分比明显缩短（P<0.05）。结论：OVX损
伤小鼠的学习记忆，LA 可改善这种损伤，内皮型一氧化氮合酶（eNOS）抑制剂L-NAME 可削弱LA 的这种保护作用。 |
| 英文摘要: |
| Objective:To investigate the influence of Lipoic acid (LA) on learning and memory abilites of Ovariectomize (OVX)
mice.Methods:2-month-old female Kunming mice (22-25 g) mice were assigned randomly to a shamoperated (Sham) group, ovariectomized
(OVX) group, ovariectomized+Lipoic acid (LA) group, and ovariectomized+ LA+L-NAME group. Morris water maze was used
to test the learning and memory abilities of mice.Results:Compared with the Shamgroup, in the OVX group, the average escape latency
detected by hidden platform trial were higher (P<0.05), the proportion of time and swim distance the mice spent searching for the platform
in the target quadrant were lower (P<0.05); as compared with the OVX group, LA shortened the escape latency (P<0.05), improve
the proportion of time and swimdistance(P<0.05); compared with the Sham group, in the OVX+LA+L-NAME group, the average escape
latency were higher (P<0.05), the proportion of time and swim distance the mice spent searching for the platform were lower (P<0.05).Conclusion:LA could improve the decreased of spatial learning and memory ability of mice which was induced by OVX. After an injection
of L-NAME, the above effects of LA were attenuated. |
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