| 李增清 杨东新 周真△ 赵小琴 赵慧 谢丹宇 郭素华 胡兢晶 王波.染色体1q12 区段IL6R 基因多态性与儿童哮喘易感性的研究[J].,2016,16(24):4684-4686 |
| 染色体1q12 区段IL6R 基因多态性与儿童哮喘易感性的研究 |
| Study on the Relationship between Genetic Polymorphisms of Interleukin-6Rand Childhood Bronchial Asthmatic Susceptibility |
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| DOI： |
| 中文关键词: IL6R 基因多态性 哮喘 儿童 |
| 英文关键词: Interleukin 6R Single nucleotide polymorphism Asthma Child |
| 基金项目:广东省自然科学基金项目（s2013010012670） |
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| 中文摘要: |
| 目的：检测染色体1q12 区段IL6R基因多态性与儿童发生支气管哮喘易感性的关系。方法：150 名支气管哮喘患儿为支气管
哮喘组。150 名健康儿童为对照组。采用质谱单核苷酸多态性(SNP)技术，对两组儿童的IL6R 基因进行分析。结果：两组IL6 基因
位点的分布符合Hardy-Weinburg 平衡定律。两组IL6R 基因rs4845374 位点的基因型与等位基因相比较，无明显差异(X2值分别
为3.442 和3.701；P值分别为0.179 和0.088)。两组IL6R基因rs2228145 位点的基因型与等位基因相比较，差异均有统计学意义
(X2值分别为6.635 和9.200；P值分别为0.036 和0.003)。IL6R 基因rs2228145 位点基因型的变异等位基因T、C 与支气管哮喘存
在密切联系，CC、TT型出现支气管哮喘的风险均比CT 型高。结论：IL6R 基因rs4845374 位点与儿童支气管哮喘无相关性，而
rs2228145 位点多态性与儿童支气管哮喘有相关性。 |
| 英文摘要: |
| Objective:To study the relationship between polymorphisms of interleukin (IL)-6R and bronchial asthma in children.Methods:A total of 150 children with bronchial asthma were included in the study as bronchial asthma group. Meanwhile, 150 healthy
children were included as control group. Then IL6R gene was analyzed by single nucleotide polymorphisms (SNP) technique.Results:IL6R gene was in Hardy-Weinburg balance. There was no significant difference in rs4845374 of IL6R gene between two groups (X2 =3.
442 and 3.701; P =0.179 and 0.088). However, there was significant difference in rs2228145 of IL6R gene between two groups (X2 =6.
635 and 9.200; P =0.036 and 0.003). There was close relationship between allele T and C in IL-6R gene rs2228145 and asthma, the risk
of asthma in CC and TT genotype was higher than that of CT genotype.Conclusion:The rs4845374 has no relationship with bronchial
asthma, while rs2228145 is related with bronchial asthma of children. |
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