| Objective:To investigate the evaluation effect of serum CYFRA21-1 and SCCAg levels on clinical pathological
features and malignant degree of nasopharyngeal carcinoma patients.Methods:55 cases of patients diagnosed as nasopharyngeal
carcinoma and treated with radiotherapy in our hospital during April 2009 to December 2010 were enrolled in experimental group, 60
cases of healthy volunteers received health examination during the same period were enrolled in the control group. The serum
CYFRA21-1, SCCAg levels and mRNA contents of Livin, CDK6, Caspase-3, Caspase-9 in tumor tissue were determined.Results:The
serum CYFRA21-1 and SCCAg levels of experimental group were significantly higher than those in control group (P<0.05); the higher
the TNMstaging and the lower the degree of differentiation, the higher the levels of serumCYFRA21-1, SCCAg and the mRNA contents
of Livin, CDK6 in tumor tissue, the lower the mRNA contents of Caspase-3, Caspase-9 in tumor tissue(P<0.05). The serumCYFRA21-1
contents were positively correlated with mRNA contents of Livin, CDK6 in tumor tissue, and negatively correlated with mRNA contents
of Caspase-3, Caspase-9 in tumor tissue, r value were separately 0.723, 0.693, -0.714, -0.648 (P<0.05); SCCAg contents were positively
correlated with mRNA contents of Livin, CDK6 in tumor tissue, and negatively correlated with mRNA contents of Caspase-3, Caspase-9
in tumor tissue, r value were separately 0.645, 0.703, -0.751, -0.681 (P<0.05).Conclusion:The serum level of CYFRA21-1 and SCCAg
in the patients with nasopharyngeal carcinoma can evaluate tumor stage, differentiation degree and cell proliferation viability in tumor
tissue, so they are ideal index for the evaluation of clinical pathological features and malignant degree. |
