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目的：研究臭氧大自血疗法治疗急性缺血性脑梗死患者的临床疗效，为临床治疗提供依据。方法：选取2014 年10 月到2015 年8 月我院收治的急性缺血性脑梗死患者210 例，按照随机数字表法将患者分为研究组和对照组，每组105 例，两组均给予常规治疗，研究组在常规治疗的基础上给予臭氧大自血疗法，应用barthel指数评定日常生活活动能力，应用美国国立卫生研究院卒中量表（NIHSS）评价神经功能缺损，比较两组临床疗效，治疗前后甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HLD-C）和低密度脂蛋白（LDL-C），并比较两组不良反应。结果：研究组总有效率为87.6％（92/105）显著高于对照组的73.3％（77/105），比较差异具有统计学意义（P＜0.05）；治疗后两组NIHSS评分显著降低，barthel 评分显著升高，且研究组NIHSS 评分显著低于对照组，barthel 评分显著高于对照组，比较差异具有统计学意义（P＜0.05）；治疗后两组TG、TC 和LDL-C 均显著降低，HDL-C 显著升高，且研究组TG、TC 和LDL-C 低于对照组，HDL-C 高于对照组，比较差异具有统计学意义（P＜0.05）；两组不良反应比较无统计学意义（P＞0.05）。结论：臭氧大自血疗法治疗急性缺血性脑梗死疗效较好，能明显改善患者的神经功能和日常生活。

英文摘要:

Objective:To study the clinical efficacy of ozone therapy in treatment of patients with acute ischemic cerebral infarction, and to provide the basis for clinical treatment.Methods:Selected 210 cases of patients with acute ischemic cerebral infarction in our hospital from October 2014 to August 2015, which were divided into study group and control group according to the random number table method,with 105 patients in each group, two groups were given conventional treatment, the study group was treated with ozone on the basis of conventional treatment,assessed the activity ability of daily life by Barthel index, and evaluated the neurological deficits by the national institutes of health stroke scale (NIHSS), compared the clinical efficacy, triglyceride (TG), total cholesterol(TC), high density lipoprotein (HLD-C) and low density lipoprotein (LDL-C) of two groups before and after treatment, and compared the adverse reactions of the two groups.Results:The total effective rate of the study groups was 87.6(92/105),which was significantly higher than 73.3%(77/105) of control group, the difference was statistically significant (P<0.05); The NIHSS score of two groups were significantly reduce after treatment, and the barthel score were significantly increased, the NIHSS score in the study group were significantly lower than control group, while barthel score were significantly higher than control group, the difference was statistically significant (P<0.05); The levels of TG, TC and LDL-C of two groups were significantly reduce after treatment, the HDL-C were significantly increased, and the levels of TG,TC and LDL-C of the study group were lower than control group, HDL-C were higher than control group, the differences were statistically significant(P<0.05); the adverse reactions of the two groups had no statistically significant (P>0.05).Conclusion:Ozone therapy in treatment of acute ischemic cerebral infarction had better clinical efficacy, which is able to significantly improve the neurological function and daily life of patient.

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