| 范军 康健 彭璐 赵兴山 郝志华.纤维蛋白原与冠心病PCI介入治疗围术期心肌梗死的相关性[J].,2016,16(22):4377-4380 |
| 纤维蛋白原与冠心病PCI介入治疗围术期心肌梗死的相关性 |
| The Correlation Analysis of Fibrinogen and Perioperative MyocardialInfarction following PCI in Patients with Coronary Heart Disease |
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| DOI： |
| 中文关键词: 纤维蛋白原 冠心病 心肌梗死 相关性 |
| 英文关键词: Fibrinogen Coronary heart disease Myocardial infarction Correlation |
| 基金项目:河北省2014 年度医学科学研究重点课题（ZD20140228） |
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| 中文摘要: |
| 目的：探讨纤维蛋白原与冠心病介入治疗围术期心肌梗死的相关性。方法：2013 年1 月到2015 年1 月，选择在我院进行诊
治的冠心病患者92 例，都给予PCI 介入手术治疗，在手术前后进行纤维蛋白原与心功能的测定，对围术期心肌梗死发生情况与
临床资料进行调查与分析。结果：所有患者都介入手术治疗成功，术后LVESVI 与LVEDVI 值都明显低于术前(P<0.05)，而术后
LVEF值明显高于术前(P<0.05)；术后患者的血浆纤维蛋白原值为3.66± 0.42 g/L，明显低于术前的7.45± 0.56 g/L(P<0.05)。围手术
期发生心肌梗死8 例，发生率为8.7%。Spearman 秩相关分析法结果显示心肌梗死发病与血浆纤维蛋白原、LVESVI、LVEDVI、
LVEF值都存在明显相关性(P<0.05)，多元Logistic 回归分析结果显示纤维蛋白原、LVESVI、LVEDVI、LVEF、年龄为导致冠心病
围术期心肌梗死的主要危险因素(P<0.05)。结论：介入手术治疗冠心病具有很好的效果，但是围术期心肌梗死的发生率比较高，纤
维蛋白原能有效反应病变状况，在心肌梗死的发生发展中起着关键性作用。 |
| 英文摘要: |
| Objective:To investigate the correlation between plasma fibrinogen and perioperative myocardial infarction following
percutaneous coronary intervention (PCI) in patients with coronary heart disease.Methods:From January 2013 to January 2015, 92
patients with coronary artery disease from our hospital were selected and were given PCI, perioperative plasma fibrinogen level and
cardiac function were examined, incidence of perioperative myocardial infarction and clinical data were investigated and analyzed.Results:PCI is successful in all the patients. The postoperative LVESVI and LVEDVI values were significantly lower than the
preoperative values (P <0.05), and the postoperative LVEF values were significantly higher than the preoperative values (P <0.05); The
postoperative plasma fibrinogen level was 3.66 ± 0.42 g/L, which was significantly lower than the preoperative value 7.45 ± 0.56 g/L
(P <0.05). 8 patients developed a perioperative myocardial infarction, the incidence rate was 8.7%. Spearman rank correlation analysis
showed that the incidence rate of myocardial infarction correlated with the plasma fibrinogen level, LVESVI, LVEDVI, LVEF values (P
<0.05). Multivariate logistic regression analysis showed the plasma fibrinogen level, LVESVI, LVEDVI, LVEF and age were the main
risk factors for perioperative myocardial infarction in patients with coronary heart disease (P <0.05).Conclusion:The PCI surgical
treatment of coronary heart disease has good effects, but the incidence of perioperative myocardial infarction is relatively high. The
plasma fibrinogen level can reflect the development of perioperative myocardial infarction and may play a key role in the development of
this disease. |
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