| 王婷婷 王东辉 陈会生 张景华 王丽.关于多发性硬化中浆样树突状细胞的研究进展[J].,2016,16(21):4197-4200 |
| 关于多发性硬化中浆样树突状细胞的研究进展 |
| Advance in Plasmacytoid Dendritic Cells of Multiple Sclerosis |
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| DOI： |
| 中文关键词: 浆样树突状细胞 多发性硬化 免疫调节 Ⅰ型干扰素 |
| 英文关键词: Plasmacytoid dendritic cell Multiple sclerosis Immunomodulatory TypeⅠinterferon |
| 基金项目: |
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| 中文摘要: |
| 多发性硬化是中枢神经系统炎症性自身免疫性疾病的典型代表，以白质脱髓鞘为主要特征。浆样树突状细胞，是专职抗原
提呈细胞，是固有免疫和适应性免疫的桥梁，在启动初级免疫应答和维持免疫耐受中发挥了重要作用。由于浆样树突状细胞可以
产生大量的细胞因子，特别是Ⅰ型干扰素，所以它与抗炎、免疫调节联系紧密。而目前Ⅰ型干扰素（beta）被认为是治疗多发性硬化的
有效的免疫调节剂。本文就浆样树突状细胞的来源、特性及其在固有免疫、适应性免疫及免疫耐受中的作用机制进行系统归纳整
理，并就其未来发展前景做一简单介绍，为进一步探索免疫调节新机制和寻求多发性硬化新的治疗靶点提供理论依据和基础。 |
| 英文摘要: |
| Multiple sclerosis(MS) represents the prototypic inflammatory autoimmune disorder of the central nervous system and
characterized by demyelination. Plasmacytoid dendritic cells(pDCs), professional antigen-presenting cells, bridge the innate and adaptive
immune systemand play a unique role in initiating primary immune responses and in maintaining tolerance. Because pDCs produce large
amounts of cytokines, particularly typeⅠ interferons, so it is with the anti-inflammatory, immunomodulatory closely. At present, typeⅠ
interferon (beta) is considered to be the effective immunomodulator in treatment of MS. In this paper, the origin and characteristics of plasmacytoid
dendritic cells and the mechanisms of actions which pDCs play in innate immunity and daptive immunity and immune tolerance
are summarized, and the future development prospects are also introduced briefly, so as to provide theoretical basis and foundation
for exploring the new immune regulation mechanisms and searching new therapeutic targets for multiple sclerosis. |
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