| 卢素娟 潘琦文 班婷 梁婵玉 陈慧峰.血清HE4，CA125 联合经阴道超声对卵巢癌的诊断价值[J].,2016,16(21):4116-4119 |
| 血清HE4，CA125 联合经阴道超声对卵巢癌的诊断价值 |
| The Diagnostic Value of SerumHE4, CA125 and Transvaginal SonographyCombined Detection for Ovarian Cancer |
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| DOI： |
| 中文关键词: 卵巢癌 人附睾蛋白4 糖类抗原125 经阴道超声 |
| 英文关键词: Ovarian cancer Human epididymis protein 4 Carbohydrate antigen 125 Transvaginal sonography |
| 基金项目:广西壮族自治区卫生厅自筹经费科研项目（Z2013530） |
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| 中文摘要: |
| 目的：探讨血清人附睾蛋白4(human epididymisprotein 4，HE4)、糖类抗原125(Carbohydrate antigen 125，CA125）联合经阴道
超声（transvaginal sonography，TVS）对卵巢癌的诊断价值。方法：选择2013 年1 月～2014 年12 月本院确诊的卵巢病变患者500
例，同期体检中心健康女性200 例作为对照组，应用酶联免疫法和化学发光分析系统检测方法分别检测其血清HE4、CA125 水
平，并进行阴道超声检查。结果：500 例卵巢病变患者经活检检查发现卵巢癌患者70 例，良性卵巢疾病患者430 例。卵巢癌组HE4
和CA125 水平均显著高于良性卵巢疾病组和健康对照组，良性卵巢疾病组HE4 和CA125 水平显著高于健康对照组，差异有统
计学意义(P<0.01)。血清HE4+CA125检测卵巢癌的敏感度为80.00 %，特异度为95.11 %；血清HE4+CA125+TVS联合检测卵巢
癌的敏感度为94.29 %，特异度为97.91 %。HE4+CA125+TVS 联合检测卵巢癌的敏感度和特异度均显著高于单项检测HE4、
CA125 或TVS（P<0.05）。结论：HE4、CA125、TVS 三者联合检测卵巢癌可以提高诊断的特异度和敏感度，对卵巢癌的诊断、治疗及
监测具有重要意义。 |
| 英文摘要: |
| Objective:To investigate the value of serumHuman Epididymis protein 4（HE4）, Carbohydrate antigen 125（CA125）
combined transvaginal sonography (TVS) in the diagnosis of ovarian cancer.Methods:From January 2013 to December 2014 in our hospital
500 patients with ovarian disease were diagnosed as objects, , and over the same period 200 cases of healthy women were selected
as a control group. Enzyme-linked immunosorbent assay and chemiluminescence detection system was used to test the serum HE4 and
CA125 level respectively and TVS were checked.Results:500 cases of ovarian disease were included 70 cases of ovarian cancer and 430
cases of patients with benign ovarian disease diagnosed by biopsy. The levels of HE4 and CA125 of ovarian cancer group were significantly
higher than those of benign ovarian disease group and the healthy control group, and the HE4 and CA125 levels of benign ovarian
disease group were significantly higher than those of the healthy control group, and the difference was statistically significant(P<0.01).
The sensitivity of serumHE4 combined with CA125 in ovarian cancer detection was 80.00 %and and the specificity was 95.11 %; while
the sensitivity of serum HE4+CA125+TVS combined detection for ovarian cancer was 94.29 %sensitivity and the specificity was 97.91
%. The sensitivity and specificity of HE4+CA125+TVS combined detection for ovarian cancer, was significantly higher than that of single
detection of HE4, CA125 or TVS.Conclusion:HE4, CA125, TVS combined detection can improve the diagnostic specificity and
sensitivity, which is of great importance for the diagnosis, treatment and monitoring of ovarian cancer. |
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