| 刘杨 李丹 马丽君 张荣丽 王超.NT-pro BNP 及D-二聚体水平变化对急性缺血性脑卒中患者预后的影响[J].,2016,16(21):4082-4084 |
| NT-pro BNP 及D-二聚体水平变化对急性缺血性脑卒中患者预后的影响 |
| Effects of NT-proBNP and D-dimer Levels on Prognosis of Acute Ischemic Infarction |
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| DOI： |
| 中文关键词: 急性缺血性脑卒中 NT-proBNP D-二聚体 |
| 英文关键词: Acute ischemic stroke NT-proBNP D-dimer |
| 基金项目:北京市自然科学基金项目（7052023） |
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| 中文摘要: |
| 目的：探讨急性缺血性脑卒中患者血浆B 型脑钠肽前体（NT-proBNP）和D-二聚体水平与病情严重程度的关系。方法：选取
2013 年6 月-2015 年6月在我院接受治疗的急性缺血性脑卒中患者81 例作为研究对象，另选取同期在我院接受健康体检的志
愿者53 例作为对照组。检测并比较两组血浆NT-proBNP 及D-二聚体水平。结果：急性脑卒中患者血浆NT-pro BNP与D-二聚
体水平均显著高于对照组，差异具有统计学意义（P< 0.05）。大面积梗死的缺血性脑卒中患者血浆NT-proBNP 及D- 二聚体水平
显著高于非大面积梗死患者，差异具有统计学意义（P<0.05）；NIHSS 评分> 10 的缺血性脑卒中患者血浆NT-proBNP 及D- 二聚
体水平显著高于NIHSS 评分≤ 10 的患者，差异具有统计学意义（P<0.05）；有意识障碍的缺血性脑卒中患者血浆NT-proBNP 及
D- 二聚体水平显著高于无意识障碍者，差异具有统计学意义（P<0.05）；随访结局为死亡的缺血性脑卒中患者血浆NT-proBNP 及
D- 二聚体水平显著高于存活者，差异具有统计学意义（P<0.05）。结论：NT-proBNP 及D-二聚体水平可以反映急性缺血性脑卒中
患者的病情，对脑卒中患者的病情评估及预后判断具有参考价值。 |
| 英文摘要: |
| Objective:To investigate the relationship between plasma levels of B-type natriuretic peptide precursor (NT-proBNP)
and D-dimer with acute ischemic stroke.Methods:81 cases who were diagnosed with the acute ischenic stroke in our hospital from June
2013 to June 2015 were selected as the research objects, and another 53 healthy volunteers were selected as the control group. Then the
plasma levels of NT-proBNP and D-dimer were detected and compared between the two groups.Results:The NT-proBNP and D-dimer
levels in the stroke group were higher than those of the control group, and the differences were statistically significant (P<0.05). The levels
of NT-proBNP and D-dimer in the patients with massive area infarction were higher than those of the patients with non-massive area
infarction, and the differences were statistically significant (P<0.05); The levels of NT-proBNP and D-dimer in the patients with conscious
disturbance were higher than those of the patients with non-conscious disturbance, and the differences were statistically significant
(P<0.05); The levels of NT-proBNP and D-dimer in the patients with the NIHSS score>10 were higher than those of the patients with the
NIHSS score<10, and the difference was statistically significant (P<0.05).Conclusion:The levels of NT-proBNP and D-dimer can reflect
the severity of acute ischemic stroke, which could provide a reference for the evaluation and prognosis of disease. |
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