| 赵国忠 王华 曹丽萍 何敏 陈晨.血清胱抑素C 水平与糖尿病心室重构关系的临床研究[J].,2016,16(21):4068-4070 |
| 血清胱抑素C 水平与糖尿病心室重构关系的临床研究 |
| Correlation of the SerumCystatin C Level with the Ventricular Remodelingin Diabetes |
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| DOI： |
| 中文关键词: 胱抑素C 糖尿病 心室重构 |
| 英文关键词: Cystatin C Diabetes Ventricular remodeling |
| 基金项目:四川省医学科研青年创新计划项目（Q15061） |
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| 中文摘要: |
| 目的：研究血清胱抑素C 水平与糖尿病心室重构的关系。方法：选择2013 年10 月～2015 年10 月在我院进行诊治的糖尿病
患者90 例，检测血清胱抑素C 水平，按照糖尿病患者血清胱抑素C水平的中位数，分为正常组(胱抑素C 水平＜1.65 mg/L)和升
高组(胱抑素C 水平＞1.65 mg/L)。行超声心动图检测左室舒张末内径、左房内径、左室舒张末容积、室间隔厚度和左室后壁厚度，
并计算出左室质量指数。对两组的这些指标进行比较，并分析血清胱抑素C 与糖尿病心室重构的相关性。结果：与正常组相比，升
高组的胱抑素C、左室舒张末内径、左房内径、室间隔厚度、左室后壁厚度、左室质量指数和脑钠肽水平均明显增高(P<0.05)；经过
相关性分析，血清胱抑素C 水平与左室舒张末内径、左房内径、室间隔厚度、左室后壁厚度、左室质量指数和脑钠肽均呈正相关
(P<0.05)；Logistic 回归分析显示左室舒张末内径、左房内径、室间隔厚度、左室后壁厚度、左室质量指数和脑钠肽等是胱抑素C 水
平升高的危险因素。结论：血清胱抑素C 水平与糖尿病患者的心功能和心室重构具有明显相关性，可作为衡量糖尿病患者心室重
构程度的一项参考指标。 |
| 英文摘要: |
| Objective:To study the serumcystatinC levels and its relevance to diabetes ventricular remodeling.Methods:Selected
80 cases of patients with diabetes who were treated in our hospital from December 2013 to December 2015. The serum cystatin C levels
were detected, according to the average levels of cystatin C, the patients were divided into normal group (cystatin C<1.65 mg/L) and elevated
group (cystatin C>1.65 mg/L). Using echocardiography to detect the left ventricular end-diastolic diameter, left atrial diameter, interventricular
septum thickness, left ventricular end-diastolic volume and left ventricular posterior wall thickness, and left ventricular
mass index was calculated. Compare these indicators of the two groups and analyze the relationship of serum cystatin C levels with diabetes
ventricular remodeling.Results:Compared with normal group, the serumcystatin C, left ventricular end-diastolic diameter, left atrial
diameter, interventricular septum thickness, left ventricular posterior wall thickness, left ventricular mass index and brain natriuretic
peptide levels of elevated group were significantly increased(P<0.05); through correlation analysis, there was a positive correlation of the
serum cystatin C level and left ventricular end-diastolic diameter, left atrial diameter, interventricular septum thickness, left ventricular
posterior wall thickness, left ventricular mass index (P<0.05); Logistic regression analysis showed that left ventricular end-diastolic diameter,
left atrial diameter, interventricular septum thickness, left ventricular posterior wall thickness, left ventricular mass index and brain
natriuretic peptide were risk factors for cystatin C.Conclusion:The serum cystatin C in patients with diabetes mellitus has obvious correlation
with cardiac function and ventricular remodeling, can be used as an indicator to measure the degree of ventricular remodeling in
patients with diabetes. |
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