| 庞婧 席超 崔菊 黄秀清 张铁梅.高果糖高脂饮食对小鼠体内能量代谢的影响[J].,2016,16(21):4006-4009 |
| 高果糖高脂饮食对小鼠体内能量代谢的影响 |
| Effects of High Fructose/High Fat Diets on Energy MetabolisminC57BL/6 Mice |
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| DOI： |
| 中文关键词: 高脂饮食 果糖 呼吸商 能量代谢 |
| 英文关键词: High fat diet Fructose Respiratory quotient Energy metabolism |
| 基金项目:国家自然科学基金青年科学基金项目（81100570）；国家科技支撑计划项目（2012BAI10B01） |
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| 中文摘要: |
| 目的：高热量物质的过度摄入是导致机体代谢紊乱，诱发2 型糖尿病等代谢性疾病的主要原因，本文通过比较高果糖、高脂
及高果糖高脂混合喂饲对小鼠体内能量代谢的影响，探索饮食诱发代谢紊乱性疾病的可能发病机制。方法：采用20%高果糖水，
60%高脂饲料，及二者混合方式饲养C57BL/6小鼠3 个月后，观察各组小鼠24 小时内氧气消耗量，二氧化碳生成量，呼吸商及能
量消耗的改变。结果：不同饮食喂饲3 个月，与对照组小鼠相比，高果糖组、高脂组、及高果糖高脂组小鼠均表现出明显的肝内脂
质蓄积，氧气消耗量增加，呼吸商下降，能量消耗增加。结论：过剩的高热量物质摄入导致机体内物质代谢、能量代谢发生改变，糖
代谢受损，脂代谢增强，能量代谢方式从糖氧化为主转变为脂氧化供能。 |
| 英文摘要: |
| Objective:Excess energy intake is a main causal reason for metabolic disorders. To investigate the possible pathogenesis
mechanism of metabolic dysfunction, the effects of different high energy foods on energy metabolism were compared.Methods:Oxygen
consumption, carbon dioxide production, respiratory quotient and energy expenditure within 24 hours were observed in C57BL/6
mice fed with 20% fructose water, 60% high fat diet, or the combination diet.Results:After 3 month feeding, all of the three energy-
dense groups showed lipid accumulation in liver, respiratory quotient decrease, and energy expenditure increase compared with control
group.Conclusion:Excess energy intake led to glucose metabolism injury and lipid metabolism increase. The pattern of energy
metabolismwas changed fromglucose oxidation into lipid oxidation as energy supplier. |
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