| 闫丽儒 李媛媛 王梅 郭玉杰 郗春艳.VEGF基因多态性和ID2基因甲基化与法洛四联症发病机制的研究现状[J].,2016,16(20):3982-3985 |
| VEGF基因多态性和ID2基因甲基化与法洛四联症发病机制的研究现状 |
| Advance of the Pathogenesis about VEGF Gene Polymorphismand ID2 GeneMethylation with Tetralogy of Fallot |
| |
| DOI： |
| 中文关键词: 法洛氏四联症 基因多态性 甲基化 |
| 英文关键词: Tetralogy of fallot Single-nucleotide polymorphism Methylation |
| 基金项目:黑龙江省自然科学基金项目( H201412) |
|
| 摘要点击次数: 736 |
| 全文下载次数: 0 |
| 中文摘要: |
| 基因的多态性改变和甲基化表观遗传的修饰是有关法洛四联症在遗传学方面研究最多的发病机制，在心脏发育过程中
VEGF基因的多态性和ID2 基因甲基化的异常改变，可以导致这些基因的转录和表达调控的异常，使心脏发育缺陷而导致法洛四
联症。通过对基因多态性和DNA 甲基化的深入研究有助于法洛四联症发病机制的探讨，为疾病的诊断和治疗开辟新思路。 |
| 英文摘要: |
| The change of Gene polymorphism and epigenetic modification of methylation was the most common pathogenesis
about genetics of tetralogy of fallot. In the process of heart development, VEGF gene polymorphism and ID2 gene methylation can cause
the heart developmental defect by abnormal regulation of these genes transcription and expression, leading to tetralogy of fallot. The
further study of gene polymorphism and DNA methylation can help us to realize the pathogenesis of tetralogy of fallot and to get new
ideas for its diagnosis and treatment. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
