| 杨秀华 郭峰 任丽娜 赵毅 武昕.TGF-beta2 和TGFbetaRⅡ在外阴鳞癌中的表达及意义[J].,2016,16(19):3751-3754 |
| TGF-beta2 和TGFbetaRⅡ在外阴鳞癌中的表达及意义 |
| Expression and Clinical Significance of TGF-beta2 and TGFbetaRⅡ in the Vulvar Squamous Cell Carcinoma |
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| DOI： |
| 中文关键词: 外阴鳞癌 转化生长因子- beta2 转化生长因子受体betaRⅡ |
| 英文关键词: Vulvar squamous cell carcinomas Transforming growth factor Transforming growth factor receptor |
| 基金项目:辽宁省自然科学基金项目(2014021057) |
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| 中文摘要: |
| 目的：探讨外阴鳞癌(VSCC)中转化生长因子-beta2(TGF-beta2)和转化生长因子受体betaRⅡ(TGFbetaRⅡ)蛋白的表达及其临床病理
意义。方法：收集30 例外阴鳞癌及10 例外阴整形时切下的外阴正常皮肤组织。所有组织来自2012 年1 月至2015 年10 月在我
院妇科行手术治疗的患者。采用免疫组化方法检测TGF-beta2及TGFbetaRⅡ蛋白的表达。结果：外阴鳞癌组织中TGF-茁2 的阳性表达
率显著高于正常外阴组织(90%vs 20 %)，差异有统计学意义(P<0.05)，TGF-beta2 的表达与肿瘤分化程度、FIGO分期无关(P>0.05)，
但与淋巴结是否转移显著相关(P<0.05)。外阴鳞癌组织中TGFbetaRⅡ的阳性表达低于正常外阴组织(13.33%vs 70 %)，差异有统计
学意义(P<0.05)，TGFbetaRⅡ的表达与肿瘤分化程度、FIGO 分期和淋巴结是否转移均无显著相关性(P>0.05)。结论：TGF-beta2 的表达
上调与外阴鳞癌的发生及其淋巴结转移有关，可能是VSCC 的治疗靶点。TGFbetaRⅡ的表达下调可能参与了外阴鳞癌的发生。 |
| 英文摘要: |
| Objective:To investigate the expression and clinical significance of transforming growth factor beta 2（TGF-beta2）and
transforming growth factor beta receptor 2 (TGFbetaRⅡ) in VSCC.Methods:30 freshly frozen VSCC samples and 10 cases of normal vulvar
squamous epithelium from patients undergoing vulva plastic surgery were collected. All of the tissues were obtained fromthe Department
of Gynaecology in our hospital at the time of surgery from January 2012 to October 2015. The expressions of TGF-beta2 and TGFbetaR
Ⅱ of the specimens were determined by immunohistochemistry method.Results:The expression of TGFbeta2 was significantly higher in
the VSCC compared with the control tissues (90 % vs 20 %)(P<0.05), the TGF-beta2 level was not correlated with the tumour differentiation
and FIGO stage (P>0.05), but was positively correlated with the lymph node metastasis of VSCC (P<0.05). The expression level of
TGFbetaRⅡ was significantly lower in the VSCC compared with control tissues (13.33%vs 70 %), the TGFbetaRⅡ level was not correlated
with tumour differentiation, FIGO stage and lymph node metastasis (P>0.05).Conclusion:The up-regulation of TGF-beta2 was found to be
associated with the tumourigenesis of VSCC and lymphatic metastasis, TGF-beta2 might be a critical therapeutic target in the VSCC.
Down-regulation of TGFbetaRⅡ might be associated with the tumourigenesis of VSCC. |
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