| 彭淑琴 王学红 张英 张立民 李青.参麦注射液与布地奈德联合治疗急性酒精中毒伴吸入性肺炎的临床研究[J].,2016,16(19):3744-3746 |
| 参麦注射液与布地奈德联合治疗急性酒精中毒伴吸入性肺炎的临床研究 |
| Shenmai Injection and Budesonide for Patients with Acute AlcoholismandAspiration Pneumonia |
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| DOI： |
| 中文关键词: 参麦注射液 布地奈德 急性酒精中毒 吸入性肺炎 疗效 |
| 英文关键词: Shenmai injection Budesonide Acute alcoholism Aspiration pneumonia Curative effect |
| 基金项目: |
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| 中文摘要: |
| 目的：探究参麦注射液与布地奈德联合治疗急性酒精中毒伴吸入性肺炎的临床疗效。方法：选择2012年6 月~2015 年6 月
期间，我院收治急性酒精中毒合并吸入性肺炎患者112 例为研究对象，采用随机数字法将其随机分为观察组（57 例）和对照组（55
例）。对照组在基础治疗的基础上给予布地奈德治疗，观察组在对照组的基础上联合参麦注射液治疗，收集并分析治疗后两组患
者症状恢复时间、症状消失时间、清醒后不良反应发生情况、治疗前后肝功能指标及血清炎性因子指标。结果：观察组患者清醒时
间、血压恢复时间及头晕、头痛、电解质紊乱的发生率均显著低于对照组（P<0.05）；治疗后两组患者间天冬氨酸氨基转移酶
（AST）、丙氨酸转氨酶（ALT）、酌- 谷氨酰基转移酶（GGT）水平均出现显著降低，且观察组均显著低于对照组（P<0.05）；观察患者咳
嗽消失、气喘缓解、哮鸣音消失及湿罗音消失时间均显著低于对照组(P<0.05)；治疗后两组患者血清IL-6、TNF-琢及CRP水平均显
著降低，且观察组均显著低于对照组（P<0.05）。结论：参麦注射液与布地奈德联合治疗急性酒精中毒伴吸入性肺炎疗效可靠，能够
有效缩短患者酒精中毒症状的恢复与消失时间，降低清醒后不良症状的发生率，并且能改善患者肝功能、减轻炎症反应，具有重
要的临床价值。 |
| 英文摘要: |
| Objective:To explore the clinical curative effect of Shenmai injection combined with budesonide in treatment of patients
with acute alcoholismand aspiration pneumonia.Methods:A total of 112 patients with acute alcoholismand aspiration pneumonia,
who were admitted to Langfang People's Hospital of Hebei Province fromJune 2012 to June 2015, were chosen and randomly divided into
observation group (n=57) and control group (n=55). The control group was treated with budesonide on the basis of basic treatment,
while the observation group was added Shenmai injection on the basis of control group's therapy. The recovery and disappeared time of
symptoms,adverse reactions, liver function indexes and serum inflammatory factors indexes in the two groups before and after treatment
were collected and analyzed.Results:The awake time, recovery time of blood pressure, and the incidence of dizziness, headache and
electrolyte disorders in the observation group were significantly lower than those in the control group (P<0.05). The levels of aspartate
transaminase(AST), alanine aminotransferase(ALT), gamma-glutamyl transferase(GGT) in the two group after treatment significantly decreased
than before treatment, and the indexes in the observation group were significantly lower than those in control group (P<0.05).
The time of cough stopping, asthma relieving, wheezing and wet rales disappearing time in the observation group were significantly
shorter than those in the control group(P<0.05). The levels of serumIL-6, CRP and TNF-alpha in the two groups after treatment significantly
decreased than before treatment, and the indexes in the observation group were significantly lower than those in the control group (P<0.
05).Conclusion:Shenmai injection plus budesonide has a reliable curative effect in the treatment of patients with acute alcoholism and
aspiration pneumonia, which can effectively shorten the recovery and disappearing time of symptoms, reduce the incidence of adverse reactions,
improve liver function and relieve the inflammatory reaction, which has an important clinical value. |
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