| 白帆 李建辉 汪春付 党便利 刘青 庄严 康文 姚娜 孙永涛△.43 例HIV/AIDS 患者抗病毒治疗情况分析[J].,2016,16(19):3658-3660 |
| 43 例HIV/AIDS 患者抗病毒治疗情况分析 |
| Analysis of the Efficacy of Antiretroviral Treatment in 43 Cases of HIV/AIDS Patients |
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| DOI： |
| 中文关键词: 人类免疫缺陷病毒 艾滋病 CD4+T 淋巴细胞 高效抗逆转录病毒治疗 |
| 英文关键词: Human immunodeficiency virus Acquired immuno deficiency syndrome CD4+T lymphocyte Highly active antiretroviral
therapy |
| 基金项目:国家" 十二五" 科技重大专项（2014ZX10001002） |
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| 中文摘要: |
| 目的：研究来第四军医大学唐都医院传染科就诊的人类免疫缺陷病毒/ 艾滋病(Human immunodeficiency virus/Acquired immuno
deficiency syndrome，HIV/AIDS)患者感染状况及抗病毒治疗效果。方法：采用前瞻性随访研究的方法，收集来我院就诊的
HIV/AIDS患者的基本信息，并对其实验室检查结果、治疗方案及后续随访结果进行分析。结果：随访观察的43 例HIV/AIDS患者
治疗前平均基线CD4+T淋巴细胞计数为(330.74± 176.35)cells/uL，CD8+T淋巴细胞计数为(1177.80± 321.49)cells/uL，CD4+，CD8+T
淋巴细胞比值为0.30± 0.19；治疗一年后平均CD4+T 淋巴细胞计数为(482.74± 217.77)cells/uL，CD8+T 淋巴细胞计数为(861.53±
282.85)cells/滋L，CD4+，CD8+T 淋巴细胞比值为0.59± 0.28。所有患者治疗一年后血浆HIV-RNA 载量均达到检测限以下(<500
copies/mL)。结论：规范的抗病毒治疗对于改善HIV/AIDS患者预后至关重要；基线CD4+T 淋巴细胞计数越低，抗病毒治疗效果越
差。 |
| 英文摘要: |
| Objective:To investigate the infection status and the effect of antiretroviral treatment (ART) on HIV/AIDS patients in
the Department of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University.Methods:The follow-up study was
conducted prospectively. The basic information of HIV/AIDS patients were collected. Laboratory examinations, therapeutic regimens and
follow-up information were analyzed.Results:In the investigation of 43 HIV/AIDS patients, the average baseline CD4+T cell count prior
treatment was (330.74± 176.35) cells/uL, CD8+T cell count was (1177.80± 321.49) cells/uL, CD4+/CD8+ ratio was 0.30± 0.19. The average
CD4+T cell count one year after treatment was (482.74± 217.77) cells/uL, CD8+T cell count was (861.53± 282.85) cells/uL,
CD4+/CD8+ ratio was 0.59± 0.28. After one year of HAART, plasma HIV-RNA load was undetectable in all patients.Conclusion:Standard
ART is helpful in improving prognosis of HIV/AIDS patients. The lower the baseline CD4+T cell counts, the poorer the ART effects. |
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