| Objective:To study the effect of sarpogrelate in the treatment of type 2 diabetic patients complicated with lower limb
arteriosclerosis obliterans (ASO).Methods:A total of 80 patients with type 2 diabetic complicated with lower limb ASO, who were
treated in Zhangjiakou Second Hospital of Hebei Province from April 2014 to May 2015, were selected and given oral sarpogrelate(100
mg, 3 times/day) for eight weeks. The changes of symptoms and signs of the limbs, the double lower limbs artery peak flow velocity,
blood glucose, blood lipid and blood rheology indexes before and after treatment were detected.Results:After 8 weeks of oral
sarpogrelate, the effective rates of subjective symptom of pain, cold feeling, intermittent strolled, numbness and lower limb ulcer were
more than 91%, and the clinical total effective rate was 93.75%. There were no significance in the left and right lower limb artery
diameter compared with before treatment (P>0.05), but the left and right lower limb artery peak flow was reduced compared with before
treatment, the difference was statistically significant (P<0.05). The levels of triglyceride, total cholesterol, low density lipoprotein, whole
blood high shear viscosity and whole blood low shear viscosity were lower than before treatment, the difference was statistically
significant (P<0.05).Conclusion:Sarpogrelate can improve the symptoms of type 2 diabetes patients with lower limb arteriosclerosis
obliterans and reduce the lower limb artery blood flow velocity, with a definite clinical effect, which is worthy of clinical application. |
