| 谢丹 胡璟 陈秀红 章艳 刘治国 张现成.醒脑静注射液对老年肺炎支原体肺炎患者血清TNF-alpha、CRP水平及免疫
功能的影响[J].,2016,16(16):3112-3115 |
| 醒脑静注射液对老年肺炎支原体肺炎患者血清TNF-alpha、CRP水平及免疫
功能的影响 |
| Effect of Xingnaojing Injection on the SerumTNF-alpha, CRP Levels andImmune Function of Elderly Patients with Mycoplasma PneumoniaePneumonia |
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| DOI： |
| 中文关键词: 醒脑静注射液 老年肺炎支原体肺炎 肿瘤坏死因子-alpha C-反应蛋白 免疫功能 |
| 英文关键词: Xingnaojing injection Senile pneumonia TNF-alpha CRP Immune function |
| 基金项目:国家自然科学基金项目（81070615） |
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| 中文摘要: |
| 目的：探讨醒脑静注射液对老年肺炎支原体肺炎患者血清肿瘤坏死因子-alpha(TNF-alpha)、C- 反应蛋白(CRP)水平及免疫功能影
响。方法：收集我院收治的老年肺炎支原体肺炎患者80例，随机分为实验组和对照组。对照组予阿奇霉素治疗，实验组在对照组
基础上加用醒脑静注射液。分别于治疗前、治疗后测定和比较两组血清TNF-alpha、CRP、CD3+、CD4+、CD8+水平，并对比较两组患者
咳嗽、头痛、发热等症状及X 线检查肺部阴影消失时间。结果：①治疗后，两组患者血清TNF-alpha、CRP水平均下降，实验组比对照组
下降更明显；CD3+、CD4+均上升，CD8+均下降，实验组较对照组上升及下降均更明显，差异有统计学意义(P＜0.05)；②治疗后，实
验组咳嗽、头痛、X 线肺部阴影等各症状及体征消失时间均明显短于对照组，差异有统计学意义(P＜0.05)。结论：醒脑静注射液可
显著降低老年肺炎支原体肺炎患者血清TNF-alpha、CRP水平，调节机体细胞免疫功能，显著改善患者的症状及体征。 |
| 英文摘要: |
| Objective:To investigate the effect of Xingnaojing Injection on the serum TNF-alpha, CRP levels and immune function of
elderly patients with mycoplasma pneumoniae.Methods:80 elderly patients with mycoplasma pneumoniae from our hospital were
selected and randomly divided into the control group and the experimental group. The control group was treated with Azithromycin and
the experimental group was treated with Xingnaojing Injection. The serum TNF-alpha, CRP, CD3+, CD4+ and CD8+ levels in the two groups
were tested and compared before and after treatment. The disappearance time of cough, headache, fever and other symptoms and X-ray
examination of the lung shadow were compared.Results:Compared with before treatment, the TNF-alpha and CRP levels in the two groups
were lower (P<0.05), the CD3+, CD4+ levels were higher (P＜0.05), the CD8+level were lower (P<0.05), and the experimental group
improved more obviously than the control group (P<0.05). Compared with the control group after treatment, the disappearance time of
symptoms and signs such as cough, headache, chest X-ray were shorter in the experimental group than that of the control group(P＜0.05).Conclusion:Xingnaojing injection could significantly reduce the serum levels of TNF-alpha, CRP levels in senile mycoplasma pneumonia
patients, regulate the cell immunity, improve the immune function and relieve the symptoms and signs. |
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