| 吴惠珍 吴恩昊 龚世凤 曹大勇 李霄.T细胞分化蛋白2在肝细胞癌中的表达及其临床意义[J].,2016,16(14):2670-2675 |
| T细胞分化蛋白2在肝细胞癌中的表达及其临床意义 |
| Expression and Clinical Significance of Mal2 in the HepatocellularCarcinoma |
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| DOI： |
| 中文关键词: 肝细胞癌 T 细胞分化蛋白2 生存时间 预后 |
| 英文关键词: Hepatocellular carcinoma T-cell differentiation protein 2 Survival time Prognosis |
| 基金项目:国家自然科学基金项目（81201926） |
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| 中文摘要: |
| 目的：观察T 细胞分化蛋白2(Mal2)在肝细胞癌(HCC)中的表达并探讨其临床意义。方法：采用免疫组织化学染色方法检测
226例HCC 患者的肿瘤组织和86 例正常肝组织中Mal2蛋白的表达情况，并分析其与HCC临床病理指标的关系。通过生存分析
比较不同Mal2 表达水平患者的生存情况，并分析影响HCC 患者生存情况的危险因素。结果：Mal2 蛋白在HCC肿瘤组织中的表
达水平显著高于正常肝组织(P<0.05)。Mal2 蛋白表达水平增高与HCC 患者血管侵犯、淋巴结转移和较高的TNM分期相关。生存
分析表明Mal2 蛋白高表达组患者术后生存率显著低于低表达组患者(P<0.05)。Mal2阳性表达、血管癌栓形成、淋巴结转移及较高
的TNM分期是影响HCC 患者术后生存时间的独立危险因素。结论：Mal2 蛋白在HCC 组织中呈过表达趋势，且与肿瘤转移密切
相关，可能在HCC 的诊断与预后判断中有一定的应用价值。 |
| 英文摘要: |
| Objective:To determine the expression and clinical significance of Mal, T-cell differentiation protein 2 (Mal2) in
hepatocellular carcinoma (HCC).Methods:The expressions of Mal2 protein in 226 cases of liver cancer tissue and 86 cases of normal
liver tissue were examined by immunohistochemistry. The relationship between Mal2 and clinical pathological index was analyzed. The
survival rate was compared by survival analysis between the different expression of Mal2 protein in HCC patients, and the risk factors of
survival were determined.Results:The expression of Mal2 protein in HCC tissue was significantly higher than that in the normal liver
tissues (P<0.05). The increased expression of Mal2 protein had closely relationship with vascular invasion, lymph node metastasis and
advanced TNM stage. The post-operation survival rate of patients with higher Mal2 expression was worse than the patients with lower
Male2 expression (P<0.05). The positive expression of Mal2, vascular invasion, lymph node metastasis and advanced TNM stage were
the independent risk factors of the survival time of HCC patients.Conclusion:Mal2 protein was over-expressed in HCC tissue, and was
closely related to the tumor metastasis. it was probably had good potential application in the diagnosis and prognosis of HCC. |
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