| 胡洁 汲玮 彭哲哲 张瑞冬 黄悦.吗啡与氢吗啡酮在小儿静脉自控镇痛中的应用效果比较[J].,2016,16(13):2469-2471 |
| 吗啡与氢吗啡酮在小儿静脉自控镇痛中的应用效果比较 |
| Comparison of the Effect of Morphine and Hydromorphone in the PatientControlled Intravenous Analgesia of Pedia |
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| DOI： |
| 中文关键词: 吗啡 氢吗啡酮 静脉自控镇痛 小儿 |
| 英文关键词: Morphine Hydromorphone Patient controlled intravenous analgesia(PCIA) Pediatric |
| 基金项目:上海浦东新区科技发展基金创新资金项目(PKJ2013-Y61) |
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| 中文摘要: |
| 目的：比较吗啡与氢吗啡酮在小儿静脉自控镇痛(PCIA)应用中的镇痛效果及副作用。方法：选取40名6~10 岁择期行下肢骨
科手术的患儿，术毕即予PCIA，随机分为两组：M 组(吗啡背景剂量15 ug/kg/h，PCA剂量15 ug/kg)和H 组(氢吗啡酮背景剂量3
ug/kg/h，PCA 剂量3 ug/kg)，每组20 例。记录患儿PCIA 后3、6、12、24 和48h 的FLACC 疼痛评分、Ramsay 镇静评分、PCA次数
及不良反应的发生情况(恶心呕吐、皮肤瘙痒、尿潴留、过度镇静、呼吸抑制)。结果：两组患儿各时间点FLACC 疼痛评分、Ramsay镇
静评分比较均无统计学差异(P均>0.05)。术后第二天，M组PCA 次数少于H 组，差异存在统计学意义(P<0.05)。M组皮肤瘙痒发
生率(15%)显著高于H组(0%)(P<0.05)，两组其余不良反应的发生情况比较均无统计学差异(P均>0.05)。结论：氢吗啡酮与吗啡用
于小儿术后PCIA 的镇痛效果和安全性相当。 |
| 英文摘要: |
| Objective:To compare the analgesic effect and side-effect of morphine and hydromorphone in pediatric patient controlled
intravenous analgesia (PCIA).Methods:Forty children, aged from 6 to 10 years, undergoing elective lower limb or hip operations
were randomly divided into 2 groups to receive postoperative PCIA. GroupM (morphine 15 ug/kg/h basal infusion and PCA doses of 15
ug/k), H (hydromorphone 3ug/kg/h basal infusion and PCA doses of 3 ug/kg). The FLACC score, Ramsay sedation score, number of
PCA boluses, and adverse reaction (such as nausea/vomiting, pruritus, retention of urine, over sedation and respiratory depression) were
recorded at 3, 6, 12, 24, 48h after PICA.Results:The comfort b scores, ramsay sedation score were similar between 2 groups (P>0.05).
There were significantly fewer demands of PCA boluses of the groupMcompared with group H(P<0.05) on Day 2 after treatment. Pruritus
as a side-effect was more severe in groupM (P<0.05). There was no difference in the incidence rates of other opioid-related side effects
between 2 groups.Conclusion:Both morphine and hydromorphone could provide appropriate analgesia and less side effects in pediatric
PCIA. |
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