| 金璐 陈丽 张燕玲 戴茹萍 陈艳平.不同麻醉药对瑞芬太尼诱发术后痛觉超敏的影响[J].,2016,16(9):1615-1618 |
| 不同麻醉药对瑞芬太尼诱发术后痛觉超敏的影响 |
| The Effect of Different Anesthetics on Remifentanil -induced PostoperativeHyperalgesia |
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| DOI： |
| 中文关键词: 瑞芬太尼 痛觉超敏 丙泊酚 七氟烷 |
| 英文关键词: Remifentanil Hyperalgesia Propofol Sevoflurane |
| 基金项目:湖南省社会发展支撑计划（2014SK3112） |
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| 中文摘要: |
| 目的：评价不同麻醉药对瑞芬太尼诱发术后痛觉超敏的影响。方法：40 只尾静脉置管成功的成年雄性SD 大鼠，根据不同麻
醉方式随机分为5 组（n=8）：七氟醚麻醉组（S组）；七氟醚+ 瑞芬太尼复合麻醉组（S+R 组）；小剂量丙泊酚麻醉组（Pro 组）；小剂
量丙泊酚+瑞芬太尼麻醉组（Pro+R 组）；大剂量丙泊酚+瑞芬太尼麻醉组（HPro+R 组）。在不同麻醉方式下建立大鼠后足切割痛
模型并维持麻醉一小时，于术前24 小时以及停药后6 小时，24 小时，48 小时测定双后足的机械痛阈（PWT）及观测以上不同时间
点切割足的累积疼痛评分（CPS）。结果：S+R 组与S组相比，停药后6小时切割足的CPS增加（P<0.05）、24 小时双后足的PWT 均
下降（P<0.05）。HPro+R 在停药后各时间点切割足的PWT 均高于Pro 组（P<0.001）、Pro+R组（P<0.01）。与Pro+R 组相比，HPro+R
组在停药后各时间点切割足的CPS 均低于Pro+R 组（P<0.05）。结论：吸入麻醉药七氟醚可加剧瑞芬太尼导致的术后痛觉过敏，而
大剂量丙泊酚可抑制瑞芬太尼诱发的术后痛觉过敏。 |
| 英文摘要: |
| Objective:To assess the effect of different anesthetics (sevoflurane, propofol) on remifentanil-induced postoperative
hyperalgesia.Methods:Forty male adult Sprague-Dawley rats in which caudal vein catheter was successfully placed were randomly divided
into 5 groups (n=8): sevoflurane anesthesia group (Group S), sevoflurane +remifentanil anesthesia group (Group S+R), low dose of
propofol anesthesia group (Group Pro), low dose of propofol+remifentanil anesthesia group (Group Pro+R), high dose of propofol+
remifentanil anesthesia group (Group HPro+R). All the rats underwent plantar incision under anesthesia with the different anesthetic
ways, respectively. Paw withdrawal threshold (PWT) and cumulative pain score (CPS) were measured at 24 h before anesthesia and 6 h,
24 h, 48 h after anesthesia.Results:Compared with group S, the CPS in the group S+R was significantly increased (P<0.05) at 6 h
post-anesthesia; the PWT of bilateral hind paws of rats in the group S+R were significantly decreased (P<0.05) at 24 h post-anesthesia.
The PWT of the incision paw of rats in the group HPro+R was significantly increased (P<0.05) as compared with that of the group Pro
and group Pro+R at 6 h, 24 h, 48 h post-anesthesia. In addition, the CPS of the incision paw in group HPro+R was significantly lower
than that of group Pro+R (P<0.05) at 6 h, 24 h, 48 h post-anesthesia.Conclusion:Sevoflurane could exacerbate the remifentanil-induced
postoperative hyperalgesia in rats, whole high dose of propofol could prevent it. |
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