| 龙子 孙全贵 张晓迪 海春旭 王欣.氧化还原敏感转录因子调控脂肪分化中的分子机制[J].,2016,16(7):1379-1385 |
| 氧化还原敏感转录因子调控脂肪分化中的分子机制 |
| Molecular Mechanism of Redox-sensitive Transcriptional Factors-RegulatedAdipocyte Differentiation |
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| DOI： |
| 中文关键词: 氧化还原 转录因子 脂肪分化 |
| 英文关键词: Redox Transcriptional factors Adipocyte differentiation |
| 基金项目:国家自然科学基金青年项目（31400724）；陕西省自然科学基金青年项目（2014JQ4135） |
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| 中文摘要: |
| 由于肥胖及肥胖相关疾病在全球范围内的日益流行，对于人们来说，清楚地认识脂肪组织如何生长变得非常重要。多项研
究结果表明，氧化还原敏感转录因子在脂肪细胞分化的过程中起到了关键的作用。通过明确氧化还原敏感转录因子调节脂肪分
化的作用机制，可以为干预脂肪分化和肥胖的形成提供理论和实验依据。本文回顾了最近的一些数据来列举包括核因子E2 相关
因子2（Nrf2），过氧化物酶体增殖物激活受体r共激活因子-1alpha（PGC-1alpha），p53,核因子kB（NF-kB）和叉头转录因子（FoxO）等氧化
还原敏感转录因子在脂肪细胞分化中起到的作用，为研究脂肪分化的分子机制和干预肥胖及其相关疾病提供新思路。 |
| 英文摘要: |
| In view of the global prevalence of obesity and obesity-related diseases, it is important to clearly understand how adipose
tissues develop. A battery of data implicated that the role of redox-sensitive transcriptional factors play an important role in
adipocyte differentiation. Understanding of the molecular mechanism of adipocyte differentiation regulated by redox-sensitive transcriptional
factors may provide theoretical and experimental foundation for the intervention of adipogenic differentiation and obesity. In this
review, the current progress detailing the role of redox-sensitive transcriptional factors in adipocyte differentiation was reviewed such as
Nrf2, PGC-1alpha, p53, NF-kB and FoxO etc. This review provides novel insights into the regulation of adipocyte differentiation by redox-
sensitive transcriptional factors and the intervention of obesity and its related disorders. |
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