| 李志华 刘宣 葛勤敏 王海嵘 潘曙明.脓毒症诊断的生物学标志物的研究进展[J].,2016,16(7):1358-1362 |
| 脓毒症诊断的生物学标志物的研究进展 |
| Progress of the Diagnosis of Sepsis on the Biological Markers |
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| DOI： |
| 中文关键词: 脓毒症 脓毒症早期诊断 预后 生物标志物 |
| 英文关键词: Sepsis Early diagnosis Prognosis Biological markers |
| 基金项目:上海市科委项目资助（13DZ19411003）；上海市卫计委项目资助（2013SY038）；国家临床重点专科建设项目资助 |
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| 中文摘要: |
| 脓毒症是由致病微生物感染引发的全身炎症反应综合征（SIRS)，合并血压降低且经快速液体复苏后血压仍不能恢复正常者
称为脓毒性休克（Septic shock)，其中一部分患者发展为多器官功能障碍综合症(MODS)。由于目前临床上仍缺乏早期敏感性诊断
手段，脓毒症病死率居高不下。每10 万人口中约50-300 人会发生严重脓毒症，其短期死亡率达20 %-25 %，当发展为脓毒性休克
时其死亡率达50 %。随着分子生物学和现代生物技术的不断发展，人们发现多种生物标志物在脓毒症的早期诊断、病情及预后判
断，疗效评估中发挥重要作用。因此深入了解脓毒症病理生理机制中不同生物标志物的意义及价值，对于脓毒症及其并发症的早
期识别及干预，降低患者病死率及改善患者生活质量有积极意义。本文综述了近几年来对脓毒症的诊断和预后有一定价值的主
要标志物及其应用。 |
| 英文摘要: |
| Human sepsis is thought to be systemic inflammatory response syndrome (SIRS) that is activated by invasive infection.
It can rapidly develop into sever sepsis, septic shock and multiple organ dysfunction (MODS). Due to lacking of sensitive diagnosis
methods, severe sepsis places a large burden on health care systems, with an incidence ranging from 50 to 300 cases and a short-term
mortality of 20 % to 25 %, reaching up to 50 % when shock is present. With the development of molecular biology and biotechnology,
many biological markers were researched about their functions of the early diagnosis of sepsis, the judge of severity and the prognostic of
the disease. Therefore, it is good for the patients to reduce the mortality and improve the life quality if the researchers know the value of
different biological markers. Here, we review the progress of different biological markers for the early diagnosis of sepsis. |
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