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目的：应用左房容积指数（LAVI）与血清N 末端脑钠肽原（NT-pro BNP）水平的变化情况评价原发性高血压（EH）患者左心室舒张功能。方法：选择2013年5 月-2015 年5 月在我院接受治疗的原发性高血压患者100 例。根据左房舒张功能将患者分为A 组（E/A＞1，且Em/Am＞1）、B 组（E/A＜1，且Em/Am＜1）、C 组（E/A＞1，且Em/Am＜1）及D 组（E/A＞2，且Em/Am＜1），。另选取同期在我院接受体检的健康志愿者100 例作为对照组。观察并比较各组LAVI及NT-pro BNP 水平，分析LAVI 与及NT-pro BNP 与原发性高血压患者左心室舒张功能的相关性关系。结果：原发性高血压患者E/A、LAVI及NT-pro BNP水平均显著高于对照组，而Em/Am则低于对照组，差异具有统计学意义（P<0.05）；原发性高血压患者中，LAVI 及NT-proBNP 水平随E/A 升高而递增，随Em/Am升高而递减，其中D 组LAVI及NT-proBNP 水平显著高于其他三组，差异均具有统计学意义（P＜0.05）。根据 Pearson 相关性分析可知结果显示，原发性高血压患者LAVI与NT-pro BNP 呈正相关关系（P<0.05），但与E/A 及Em/Am 无明显相关关系（P>0.05）。LAVI的截断值为29.040，NT-pro BNP为2.065 时评价左室舒张功能存在异常的敏感度及特异度均较高（P<0. 05）。结论：LAVI及NT-proBNP可较好地评价EH患者左室舒张功能情况，且：LAVI及NT-pro BNP 二者之间联系紧密与原发性高血压存在一定的相关性，两者均能较为准确的评价原发性高血压患者的左心室舒张功能，值得在临床给予推广应用。

英文摘要:

Objective:To evaluate the left ventricular diastolic function in patients with essential hypertension (EH) by left atrial volume index (LAVI) and serum NT-pro BNP.Methods:100 patients with essential hypertension who were treated in our hospital from May 2013 to May 2015 were selected,and according to the different ventricular diastolic function, the . PaPatients were divided into the group A (E/A >1, Em/Am >100), group B (Em/Am <1, E/A <1), group C (E/A 1, Em/Am <1) and group D (E/A＞2, Em/Am＜1). And another 100 healthy volunteers who had taken the examination in our hospital were selected to be the control group. Then the oLAVI and NT-pro BNP levels of patients were observed and compared the levels of LAVI and NT-pro BNP, and the correlations between the LAVI and theto analyze the correlation between LAVI and NT-pro BNP and left ventricular diastolic function of patients with in essential hypertension were analyzed.Results:LAVI, NT-pro BNP and E/A were significantly higher in patients with essential hypertension than those of patients in the control group, while Em/Am was lower than that of the patients in the in control group (P<0.05). The levels of NT-pro BNP and LAVI increased with the increase of E/A, and decreased with the increase of Em/Am and NT-pro BNP in patients with essential hypertension (P<0.05). The, and the levels of LAVI and Em/Am in D group D were significantly higher than those of patients in the other three groups (P<0.05). According toTh the correlation analysis showed that of Pearson, NT-pro BNP and LAVI were positively correlated (P<0.05), and there was no significant correlation between E/A and Em/Am (P>0.05). The sensitivity and specificity of the evaluation of the left ventricular diastolic function were better when the cutoff value of LAVI was 29.040, and the cutoff value of sensitivity and specificity of NT-pro BNP was 2.065, which was higher than that of the left ventricular diastolic function (P<0.05).Conclusion:LAVI and NT-pro BNP can evaluate left ventricular diastolic function in patients with EH, and there is he relationship between the two is closely correlation between themand EHrelated, which is worthy of promotion and application toin clinical diagnosis.

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