| Objective:To evaluate the clinical value of HPV L1 capsid protein combined with hTERC gene in diagnosing CIN2+
in Uygur and Han women.Methods:Patients with HPV positive or abnormal cells (≥ ASC-US) or both items positive were enrolled.
HPV L1 capsid protein was detected with immunocytochemistry, and hTERC gene with enzyme-linked immuno sorbent assay. The expression
rate of HPV L1 capsid protein and its diagnostic value for high-grade CIN (CIN2+) and SCC was analyzed.Results:The area under
curve was 0.577 for Uygur women and 0.572 for Han women for HPV L1 capsid protein combined with hTERC gene applied in diagnosing
CIN2+ from normal or chronic inflammation and CIN1, and 0.706 for Uygur women and 0.699 for Han women for HPV L1capsid
protein combined with hTERC gene applied in diagnosing CIN2+ from CIN1. For Uygur women, the sensitivity, specificity, accuracy,
false positive rate, false negative rate, positive predictive value and negative predictive value were 92.37％, 48.84％, 81.61％ , 15.38％ ,
32.26％, 84.62％ and 67.74％, respectively. For Han women, he sensitivity, specificity, accuracy, false positive rate, false nega- tive rate,
positive predictive value and negative predictive value were 93.69％, 46.15％, 81.33％, 16.80％, 28.00％, 83.20％ and 72.00％, respectively.
No statistical difference was found between Uygur and Han women (P>0.05).Conclusion:HPV L1 capsid protein combined with
hTERC gene should be applied in the population with CIN for diagnosing CIN2+, and the diagnostic value was equal be- tween Uygur
and Han women. |
