| 古丽美热·艾买如拉 凯赛尔江·多来提 古丽尼沙·克力木 梁静 董建江.维药罗补甫克比日丸对DM性勃起功能障碍大鼠性激素水平的影响[J].,2016,16(6):1043-1046 |
| 维药罗补甫克比日丸对DM性勃起功能障碍大鼠性激素水平的影响 |
| The Effect of Luobupukebiriwan on the SerumSex Hormones Levels ofErectile Dysfunction with Diabetes Mellitus Rats |
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| DOI： |
| 中文关键词: 罗补甫克比日丸 糖尿病 勃起功能障碍 性激素 |
| 英文关键词: Luobupukebiriwan Diabetes mellitus Erectile dysfunction Sex hormones |
| 基金项目:新疆医科大学科研创新基金项目(XJC201319)；新疆医科大学校内支撑学科项目(XYDXK50780301) |
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| 中文摘要: |
| 目的：揭示维药罗补甫克比日丸对糖尿病（DM）性勃起功能障碍（ED）大鼠性激素水平的影响。方法：取50 只SD雄性大鼠，
从中随机取7 只设为正常对照（A）组，余43 只行腹腔注射链尿佐菌素（STZ）制造DM 动物模型，未成模者为STZ组，成模者用阿
朴吗啡（APO）筛选DM性ED模型，并将其随机分为DM 性ED 对照组、药罗补甫克比日丸（C）组、胰岛素（D）组、联用（E）组，未
成ED模者为DM（Ｆ）组，共7 组。药物干预6 周后，检测外周血中性激素水平。结果：正常对照（A）组、DM性ED 胰岛素（D）组、
DM性ED联用（E）组、STZ（G）组睾酮（T）水平显著高于DM 性ED 对照（B）组、DM性ED伊木萨克（C）组、DM（F）组，有显著性
差异（P＜0.01）；正常对照（A）组、STZ（G）组促黄体生成激素（LH）水平显著低于DM 性ED 伊木萨克（C）组、DM 性ED 联用（E）
组，有显著性差异（P＜0.05、P＜0.01）；DM 性ED 对照（B）组、DM 性ED补甫克比日丸（C）组促卵泡刺激素（FSH）水平显著低于
DM性ED胰岛素（D）组、DM 性ED 联用（E）组，有显著性差异（P＜0.01、P＜0.05）。结论：维药罗补甫克比日丸可显著改善DM
性ED大鼠睾酮水平，且与胰岛素联用优于单用，维药罗补甫克比日丸治疗DM 性ED 的作用机制可能与T、LH、FSH 含量变化有
关。 |
| 英文摘要: |
| Objective:To explore the effect of luobupukebiriwan on the serum sex hormones levels of erectile dysfunction (ED)
with diabetes mellitus (DM) rats.Methods:43 Male Sprague-Dwaley rats were injected with streptozotozin (STZ) to make experimental
models of DM, then injected with apomorphine (APO) in all of the DMrats to select erectile dysfunction rats models with diabetes. The 7
normal rats is in the Normal (A) group, the ED rats were divided into the model (B) group, the luobupukebiriwan (C) group, the insulin
(D) group , the luobupukebiriwan with insulin (E) group; the rats without erectile dysfunction were called the DM (G) group; the rats
without diabetes were called the STZ(F) group. After 6 weeks, the serum sex hormones levels were detected.Results:The testosterone(T)
in group A,D,E and G was higher than that of group B, C and F (P<0.01); the luteinizing hormone(LH) in group A and G was lower than
that of group C andE (P<0.01, P<0.05); the follicle stimulating hormone (FSH) in group B and C was lower than that of group D and E
(P<0.01, P<0.05).Conclusion:Luobupukebiriwan can significantly increase serum testosterone level of ED with DMrats, which may be
related to the change of T, LH and FSH, and the effect will be better when Luobupukebiriwan is used combined with insulin rather than
single-use. |
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