| 陈素珠 李汉梁 王冰梅.组蛋白去甲基化酶在发育和再生医学的研究[J].,2016,16(4):789-792 |
| 组蛋白去甲基化酶在发育和再生医学的研究 |
| The Research Progress of Histone Demethylase in Development andRegenerative Medicine |
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| DOI： |
| 中文关键词: 表观遗传 组蛋白去甲基化酶 发育 再生 |
| 英文关键词: Epigenetic Histone demethylases Developmental biology Regenerative medicine |
| 基金项目:国家自然科学基金项目（81200761）；教育部博士点基金项目（20123503120005）；福建省自然科学基金项目（2011J01146）；
福建省教育厅科技项目（JA12081）；福建师范大学优秀青年骨干教师培养基金（fjsdjk2012077） |
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| 中文摘要: |
| 表观遗传学调控在器官发育以及再生医学中是重要的研究内容，而组蛋白的甲基化修饰属于表观遗传学调控机制之一并
且成为近年来研究的热点内容。处于不同甲基化状态下的组蛋白，能影响多种分子对其的识别和结合，在转录起始、转录效率和
转录后加工等多个层面调控相关基因的表达。而哺乳动物的器官发育与细胞重编程都与基因选择性表达密切相关，因此组蛋白
甲基化状态在基因选择性表达中扮演着重要角色。本文概述了组蛋白去甲基化酶的分类以及组蛋白不同甲基化状态下对于基因
的表达的调控，同时总结了组蛋白去甲基化酶在维持胚胎干细胞的多分化潜能和IPS细胞重编程效率方面的作用以及组蛋白去
甲基化酶基因的缺失与相关器官发育的影响。最后探讨了组蛋白甲基化修饰酶在推动发育生物学与再生医学研究进展方面的潜能。 |
| 英文摘要: |
| Epigenetic regulation is an important research content in development of organ and regenerative medicine. Histone
methylation is one of the important mechanisms of epigenetic regulation. Depending on the different state of histone methylation, the
expression of genes can be regulated at transcription initiation, transcription efficiency and posttranscriptional modification by identifying
and combining with histones. The methylation status of histone is important for selective expression of genes, which is also closely
related with the development of mammalian and reprogramming of cell. This review focuses on the classification of histone
demethylases, the function of histone demethylases in maintaining the differentiation potential of the embryonic stem cell, the role of
histone demethylases in IPS cell reprogramming, and the lose of function research on histone demethylases in the organ development. At
the end, this study discuss that the histone demethylases may have the potential to promote the research progress on developmental
biology and regenerative medicine. |
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