| 蒋灵冬 胡乐婧 林丽 冯珊珊 李小达.高强度聚焦超声在药物控制释放的应用及进展[J].,2016,16(4):775-777 |
| 高强度聚焦超声在药物控制释放的应用及进展 |
| Progress and Application of High-intensity Focused Ultrasound in ControlledDrug Delivery |
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| DOI： |
| 中文关键词: 高强度聚焦超声 热敏脂质体 控制释放 药物释放系统 |
| 英文关键词: High-intensity focused ultrasound (HIFU) Thermosensitive liposomes (TSL) Controlled release Drug delivery systems
(DDS) |
| 基金项目:国家自然科学基金项目（21273014） |
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| 中文摘要: |
| 高强度聚焦超声能够以一种非侵入性的方式有效地穿透身体内部组织，聚焦在深层组织中一个很小的空间区域内，产生很
强的声能，这些能量被组织吸收引起局部温度的升高。当温度到达热敏脂质体的相变温度时，磷脂烷基链构象的会发生改变，导
致脂质体的通透性增强，从而能够促进药物的释放。因此，高强度聚焦超声可以被用作外源刺激控制体内特定位置热敏脂质体的
药物释放。本文对高强度聚焦超声在药物控制释放领域的应用及进展进行综述。 |
| 英文摘要: |
| High-intensity focused ultrasound (HIFU) can effectively penetrate deep into the interior of the body and be focused in
a small spatial region in deep tissue in a noninvasive way, leading to high levels of acoustic energy, which is absorbed by the tissue
resulting in local temperature increase. When the temperature reaches the phase transition melting temperature (Tm) of the liposomal
bilayer, the alkyl chains of the phospholipids will experience a conformational change, leading to an increase in the permeability of the
lipid bilayer, resulting in liposomal drug release Therefore, HIFU can be used as an external stimulus for local drug release from
thermosensitive liposomes (TSL) at the desired location within the body. This review gives an overview of the application and progress of
HIFU in drug delivery areas. |
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