| 郭利明 曾小飞 尚观胜 郝明 赖雁 晏伟.FOXP3 在食管癌中表达规律研究[J].,2016,16(4):709-712 |
| FOXP3 在食管癌中表达规律研究 |
| FOXP3 Expression in Esophageal Cancer Research |
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| DOI： |
| 中文关键词: FOXP3 食管癌 表达规律 研究 |
| 英文关键词: FOXP3 Esophageal cancer Express law Research |
| 基金项目:四川省卫生厅科研课题（090117） |
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| 中文摘要: |
| 目的：研究FOXP3 在食管癌中表达规律。方法：选择2010 年1 月～2010 年10 月在我院接受手术治疗的食管鳞癌患者48
例，选取所有患者肿瘤组织及正常食管黏膜组织进行免疫组化分析，观察FOXP3 在食管癌细胞系Eca-109、正常食管黏膜细胞系
Eca-109、人食管癌组织、正常食管黏膜组织的表达，FOXP3在不同年龄、性别、肿瘤分化程度、肿瘤直径、淋巴结转移上的表达。结
果：FOXP3 在食管癌组织中阳性表达率（85.42 %）显著高于正常食管黏膜组织（14.58 %），P＜ 0.05。FOXP3 在正常细胞系表达为阴
性，在食管癌细胞系Eca-109 中的表达阳性，FOXP3在正常食管黏膜组织中表达阴性，在食管癌组织中表达阳性。在食管癌组织
中，FOXP3 阳性表达率和食管癌患者的性别、年龄等不同临床病理特征均无关联（P＞0.05），和T 分期、TNM 分期、肿瘤直径、淋
巴结转移、远处转移等存在关联（P＜0.05）。结论：食管癌细胞能够表达FOXP3，且其表达水平和食管癌的进展关系密切，可以作
为临床诊断及治疗食管癌的重要参考指标。 |
| 英文摘要: |
| Objective:Studying the express rule of the FOXP3 in esophageal cancer.Methods:48 patients with esophageal
squamous cell carcinomas undergoing surgery treatment in our hospital were chose from January 2010 to October 2010, all patient's
tumor tissue and normal esophageal mucosa tissues were selected for immunohistochemical analysis, Observed the FOXP3 expression in
Eca-109, normal esophageal mucosa esophageal cancer cell lines Eca-109, human esophageal cancer tissue and normal esophageal
mucosa tissues, surveyed the FOXP3 expression in different age, sex, tumor differentiation, tumor size, lymph node metastasis.Results:The positive expression rate of FOXP3 in esophageal cancer (85.42 %) is significantly higher than that of normal esophageal mucosa
tissues (14.58 %), P < 0.05. The FOXP3 expression are negative in normal cell lines and normal esophageal mucosa tissues, are positive
in Eca-109 esophageal cancer cell lines and esophageal cancer tissues. In esophageal cancer tissues, FOXP3 positive expression rates are
no correlation with different clinical pathological characteristics such as gender, age, there were no correlation (P>0.05), are associated
with T stag, TNM stage, tumor size, lymph node metastasis, distant metastasis, such as correlation (P<0.05) in the esophageal cancer
patients.Conclusion:Esophageal cancer cells are able to expess the FOXP3, and there is a close relationship between the expression
level and the esophageal progress. So it can be used as an important reference index of clinical diagnosis and treatment of esophageal
cancer. |
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