| 徐蔷 夏静 宋佳 王园 黄尊.长春新碱阳离子纳米结构脂质载体及其小肠吸收的研究[J].,2016,16(3):435-437 |
| 长春新碱阳离子纳米结构脂质载体及其小肠吸收的研究 |
| Vincristine Cationic Nanostructured Lipid Carriers and Intestinal Absorption |
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| DOI： |
| 中文关键词: 硫酸长春新碱 纳米结构脂质载体 阳离子 吸收促进 小肠吸收 |
| 英文关键词: Vincristine NLC Cation Absorption enhance Intestinal absorption |
| 基金项目: |
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| 中文摘要: |
| 目的：硫酸长春新碱作为一种细胞毒型抗肿瘤药物，临床上多用其注射剂，虽应用广泛，但存在较多缺点，如药物半衰期短，
代谢速率快以及毒副作用明显。本文目的是制备包载长春新碱和十二烷基磺酸钠的阳离子纳米结构脂质载体，并对其进行评价。
方法：用复乳挥发法制备出目标脂质纳米粒；利用激光粒度仪对其粒径及zeta 电位进行检测；利用高效液相色谱法对其包封率和
载药量进行测定；透析法检测纳米粒的体外释放行为；用小肠吸收法评价纳米粒的促进吸收作用。结果：制得的纳米粒的平均粒
径为(192.4± 4.14) nm，多分散系数（PDI）为0.184± 0.015，包封率为32.28 %，Zeta 电位为(30.6± 4.09) mV，载药量为（1.56± 0.10）
%；体外释放实验显示在pH=7.4 的中性释放介质中，硫酸长春新碱脂质纳米粒表现出缓释特性；小肠吸收实验表明十二烷基磺酸
钠的加入和阳离子纳米粒的修饰可提高小肠对药物的吸收。结论：阳离子硫酸长春新碱纳米结构脂质载体具有缓释效果，并可以
促进小肠对药物的吸收。 |
| 英文摘要: |
| Objective:Vincristine sulfate is a kind of cytotoxic anticancer drugs. Although its injection is widely used clinically,
there are some drawbacks such as short half-life drugs, rapid metabolic rate and significant side effects should be overcomed. The purpose
of this article is to prepare and evaluate the characteristics of nanostructured lipid carriers loaded with vincristine sulfate and sodium
dodecyl sulfonate.Methods:The target lipid nanoparticles were prepared by double emulsion volatile; its size and zeta potential were
tested by laser particle size analyzer; its encapsulation efficiency and drug loading were measured by HPLC; the release behavior was
studied by dialysis method; the promoting effect of nanoparticles' absorption was evaluated by intestinal absorption.Results:The average
particle size of nanoparticles was (192.4± 4.14) nm, the polydispersity index (PDI) was 0.184± 0.015, the encapsulation efficiency was
32.28 %, Zeta potential was (30.6± 4.09) mV, drug loading was (1.56± 0.10) %; in vitro release experiments showed that vincristine sulfate
lipid nanoparticles exhibit sustained release characteristics when media pH was 7.4; intestinal absorption experiments showed that
the addition of sodium dodecyl sulfonate and nanoparticles structure can increase the intestinal absorption of drugs.Conclusion:Vincristine
Cationic nanostructured lipid carrier has sustained-release effect, and can promote intestinal absorption of drugs. |
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