| 陈丽竹 张蓉 苗晴晴 沈炎冰 尹芹 吴飞.抗坏血酸在高粘度聚乙烯醇胶体溶液中分散均一性考察[J].,2016,16(1):16-20 |
| 抗坏血酸在高粘度聚乙烯醇胶体溶液中分散均一性考察 |
| The Uniformity of Ascorbic Acid Dispersed in Polyvinyl Alcohol ColloidalSolution with High Viscosity |
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| DOI： |
| 中文关键词: 抗坏血酸 聚乙烯醇 胶体溶液 t 检验 均一性 |
| 英文关键词: Ascorbic acid Polyvinyl alcohol Colloidal solution T-test Uniformity |
| 基金项目:国家自然科学基金项目（81173001） |
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| 中文摘要: |
| 目的：考察了采用实验室常用的磁力搅拌法和改进的机械搅拌法后，聚乙烯醇胶体溶液中抗坏血酸的分布均一度。接着，在
机械搅拌法的基础上，研究了抗坏血酸粉末与抗坏血酸溶液在胶中分散的均一性。方法：分散混合方法：机械搅拌法，磁力搅拌
法；均一性检验方法：以单位质量胶载药量RSD 值作为指标；统计学分析方法：t检验。结果：采用磁力搅拌法不能够较好地混合抗
坏血酸与PVA胶体溶液；而机械搅拌法RSD值控制在10 %以内，说明胶中抗坏血酸均一分布，符合生产要求。T检验表明两种
方法具有显著性差异。药物溶于水后分散更为均一。结论：解决药物在高粘度溶液介质中均匀分散的问题。 |
| 英文摘要: |
| Objective:We investigated the uniformity of the ascorbic acid dispersed in PVA solution by using two different methods
including traditional magnetic stirring method and the improved mechanical stirring method. Then, based on the mechanical mixing
method, the homogeneity of ascorbic acid solution and ascorbic acid powder dispersed in PVA solution was studied.Methods:Disperse
method: magnetic stirring method, mechanical stirring method: statistical method: t-test.Results:The uniformity of ascorbic acid dispersing
in the PVA solution by magnetic stirring method is 66%while using mechanical stirring method, the RSD control within 10 %, indicating
a uniform distribution of ascorbic acid in the gel solution. The result of T test shows that there is a significant difference between
the two methods. Besides, better uniformity is obtained if the ascorbic acid is dissolved into water before mixed with the gel solution.Conclusion:This article solves the uniformity problemof drug dispersed in the mediumsolution with a high viscosity. |
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