| 郝建学 王明昊 任康 秦洪 邸丽萍 刘锁利 李雪波 张云.不同移植物对兔前叉韧带重建术后血运变化的影响[J].,2015,15(36):7037-7039 |
| 不同移植物对兔前叉韧带重建术后血运变化的影响 |
| Effects of Autologous and Allogeneic Graft Semitendinosus Reconstructionon the Revascularization of Anterior Cruciate Ligament of Rabbits |
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| DOI： |
| 中文关键词: 半肌腱重建 前交叉韧带 血管生成 自体移植物 同种异体移植物 |
| 英文关键词: Semi tendon reconstruction Anterior cruciate ligament Angiogenesis Autograft Allograft |
| 基金项目:北省自然科学基金项目(C2009001072) |
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| 中文摘要: |
| 目的：比较自体和同种异体半肌腱重建兔前叉韧带对血管生成的影响。方法：选择48 只骨骼发育成熟的新西兰种属兔作为
研究对象，将其随机分为自体组(A 组)和异体组(B 组)，每组24 只，分别接受半肌腱重建前叉韧带手术。从手术日期开始，分别记
录手术后第3 周、第6 周、第12 周和第24 周重建韧带的血管生成情况同时对血管生成数量进行定量。结果：手术后两组实验兔
关节均无肿胀，关节囊无炎性反应发生。在手术后第3 周，两组血管生成无明显差异(P>0.05)；术后第6 周和第12周，自体移植组
新生血管数量明显高于异体移植组(P<0.05)；术后第24 周，异体组新生血管数量明显高于自体组(P<0.05)。结论：在兔前叉韧带的
重建过程中，异体移植物重建的血管生成速度和数量明显慢于自体移植物，提示在临床上选择自体移植物对术后恢复更理想. |
| 英文摘要: |
| Objective:To compare the effects of autologous and allogeneic graft semitendinosus reconstruction on the
revascularization of anterior cruciate ligament of rabbits.Methods:The skeletal maturity of 48 New Zealand rabbits were selected as
research subjects and randomly divided into the autologous group (A) and the allograft group (B) respectively, which accepted half fork
tendon ligament reconstruction surgery. Since the date of surgery, the ligament reconstruction angiogenesis and the number of
angiogenesis quantified were recorded.Results:No joint swelling, joint capsule and inflammatory reaction was observed in both groups
after surgery. No significant difference in angiogenesis was found in the first three weeks after surgery (P>0.05). on the 6th and 12th
week, the number of new blood vessels in autograft group was significantly higher than that of the allograft group (P <0.05); on the 24th
weeks, the number of new blood vessels in allogeneic group was significantly higher than that of autologous group (P<0.05).Conclusion:During the reconstruction process of anterior Cruciate Ligament, the angiogenesis of allograft reconstruction was slower
than autograft, suggesting that autograft had better clinical significances. |
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