| 高海娜 刘琦 张宁 王宏 刘慧 孙慧峰.蜂花烧烫伤膏对深Ⅱ度烧伤大鼠TNF-alpha、IL-10 含量的影响*[J].,2015,15(36):7021-7023 |
| 蜂花烧烫伤膏对深Ⅱ度烧伤大鼠TNF-alpha、IL-10 含量的影响* |
| Effect of Fenghua Scald Ointment on the Content of TNF-alpha and IL-10 in RatswithⅡ-degree Deep Burn |
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| DOI： |
| 中文关键词: 烧伤 蜂花烧烫伤膏 肿瘤坏死因子-alpha 白细胞介素-10 |
| 英文关键词: Scald Fenghua Scald Ointment Tumor necrosis factor-alpha Interleukin-10 |
| 基金项目:黑龙江省自然科学基金项目(D201013) |
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| 中文摘要: |
| 目的：探究蜂花烧烫膏对深Ⅱ度烧伤大鼠肿瘤坏死因子-alpha(TNF-alpha)、白细胞介素-10 (IL-10)含量的的影响。方法：采用沸水烧
伤的方法，创建大鼠深Ⅱ度烧伤的模型，大鼠分成空白对照组、烧伤复苏组、京万红组和蜂花烧烫伤膏组。并检测烧伤后1、3、6、
12、24、48 h 六个时间点TNF-alpha和IL-10 的含量变化。结果：与空白对照组比较，烧伤复苏组在烧伤后1 h血浆TNF-alpha、IL-10 的含
量明显升高，具有显著统计学意义(P＜0.01)，TNF-alpha的含量在12 h达峰值，IL-10 的含量在24 h达峰值，之后逐渐下降，但仍保持
较高水平。蜂花烧烫伤膏组与烧伤复苏组比较，血浆TNF-琢的含量六个时间点明显减少，血浆IL-10 的含量在1，3，6，12 h时间点
变化趋势基本一致，在24，48 h 低于烧伤复苏组，具有显著统计学意义(P＜0.01)；与京万红组血浆TNF-alpha、IL-10 的含量对应时间
点趋势基本一致，但含量差异有统计学意义(P＜0.01)。结论：深Ⅱ度烧伤大鼠血浆TNF-alpha、IL-10 含量有明显升高，蜂花烧烫伤膏可
通过降低血浆TNF-alpha和升高IL-10 水平而发挥抗炎作用。 |
| 英文摘要: |
| Objective:To study effect of Fenghua scald ointment on the content of Tumor-necrosis-factor-alpha(TNF- alpha) and
Interleukin-10 (IL-10) in rats with Ⅱ-degree deep burn.Methods:The method of boiling-water burn was used to build the model of rats
with Ⅱ -degree deep burn, and the rats were divided into four groups, including the control group, the resuscitation-after-burned group,
the Jingwanhong-used group and Fenghua-scald- ointment-used group. The content changes of TNF-alpha and IL-10 for each group were
measured at the time of 1 h, 3 h, 6 h, 12 h, 24 h, 48 h after rats were burned.Results:Compared with that in the control group, the content
of TNF-琢and IL-10 in plasma in the resuscitation-after-burned group became higher with statistical significance (P <0.01) after 1 h，and
then TNF-琢reached its peak around 12 h and IL-10 reached its peak around 24 h, after that, both of them decreased but still remained at
a higher level. In the Fenghua-scald- ointment group, the content of TNF-琢in plasma decreased significantly at all of six time-points, and
IL-10 in plasma was with the same trend at each time of 1 h, 3 h, 6 h, 12 h but lower with statistically significance (P <0.01) at 24 h, 48 h,
compared with that in the resuscitation-after-burned group. Compared with that in the Jingwanhong group, the content of TNF-alpha e Fenghua-scald- ointment group had the same trend at each corresponding time but with statistical significance (P <0.
01).Conclusion:The content of TNF-alpha and IL-10 in rats plasma were significantly increased after Ⅱ-degree deep burn, and Fenghuascald-
ointment has anti-inflammatory effect by reducing TNF-alpha and increasing IL-10. |
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