| 牛越 侯晓峰 樊华 范立娜 石小宇 郭晓东.CD90 在肝细胞肝癌组织中的表达及其与肝癌临床病理特征的关系[J].,2015,15(33):6522-6524 |
| CD90 在肝细胞肝癌组织中的表达及其与肝癌临床病理特征的关系 |
| Expressions of CD90 in Hepatocellular Carcinoma and the Relationshipwith Clinical Pathological Features |
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| DOI： |
| 中文关键词: 肝细胞肝癌 干细胞标记物 CD90 病理特征 |
| 英文关键词: Hepatocellular carcinoma Stemcell markers CD90 Pathological features |
| 基金项目:国家自然科学基金项目（30694021） |
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| 中文摘要: |
| 目的：探讨CD90 在肝细胞肝癌（HCC）患者肿瘤组织中的表达及其与临床病理参数的关系，为HCC 的临床治疗提供参考。
方法：选择2014 年3 月-2015 年3 月在我院接受治疗的HCC 患者80 例，收集患者肿瘤组织及癌旁组织，另选择同期就诊的80
例正常肝脏组织作为对照组。观察并比较CD90 在肝癌组织、癌旁组织及正常肝脏组织中的表达情况。结果：CD90 在肝癌组织、
癌旁组织及正常肝脏组织中呈不同程度阳性表达（P<0.05）。CD90 在肝癌组织和癌旁组织中的表达显著高于正常肝脏组织，差异
具有统计学意义（P<0.05）。CD90 在肝癌组织中的表达显著高于癌旁组织，差异具有统计学意义（P<0.05）。CD90 在HCC 组织中
的表达与肿瘤大小、肝内转移、TMN 分期和病理分级有关（P<0.05）。结论：CD90 在肝癌组织中呈高表达，其表达水平与肝癌临床
病理参数有关，可以作为HCC 诊断、治疗及预后评估的参考指标。 |
| 英文摘要: |
| Objective:To explore the expressions of CD90 in hepatocellular carcinoma and the relationship with clinical
pathological parameters in order to provide a reference for clinical researches.Methods:80 patients with hepatocellular carcinoma who
had taken the resection surgery in our hospital from March 2014 to March 2015 were selected, and the HCC cancer tissues and the
para-carcinoma tissues were collected. Another 80 normal liver tissues were collected as the control group. Then the expressions in the
tumor tissues, the para-carcinoma tissues and the normal tissues were detected and the relationship with clinical pathological parameters
was analyzed.Results:There were statistically significant differences about the expressions of CD90 in the tumor tissues, the
para-carcinoma tissues and the normal tissues (P<0.05). The expressions of CD90 in HCC tissues and para-carcinoma tissues were higher
than that of the normal tissues (P<0.05). The expression of CD90 in HCC tissues was higher than that of the para-carcinoma tissues (P<0.
05). The expression of CD90 in HCC tissues was relative with the tumor size, the intrahepatic metastasis, the TMN stages and the
pathological grades (P<0.05).Conclusion:The expression of CD90 increased in cancer tissues, which is closely relative with clinical
pathological parameters of HCC, that could provide a reference for diagnosis, treatment and prognosis of patients. |
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