| 彭明政 彭菲 李钊 周建华 林强.肺磨玻璃结节中ki-67 的表达及与P53, EGFR, CEA相关性研究[J].,2015,15(32):6206-6211 |
| 肺磨玻璃结节中ki-67 的表达及与P53, EGFR, CEA相关性研究 |
| The Expression of ki-67 in Ground-glass Opacity (GGO) and its Relationwith P53, EGFR, CEA |
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| DOI： |
| 中文关键词: 肺磨玻璃结节 GGO ki-67 p53 ROC |
| 英文关键词: Ground-glass opacity ki-67 Correlation p53 ROC |
| 基金项目:国家自然科学基金项目（81372521） |
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| 中文摘要: |
| 目的：为探究不同病理类型的肺磨玻璃结节（ground-glass opacity, GGO）中ki-67 的表达情况及其与肺癌相关标志物p53、
p63、EGFR 等表达的相关性。方法：收集从2012 年10 月至2014 年10 月我院胸外科收治的254 例GGO病人的临床病史、影像、
病理及血常规等资料予以回顾性分析。结果：Ki-67表达量从良性组（n=66），不典型腺瘤样增生（atypical adenomatous hyperplasia,
AAH, n=27），到原位癌（adenocarcinoma in situ, AIS, n=11），微浸润腺癌（minimally invasive adenocarcinoma, MIA, n=108），最后到
浸润性腺癌（invasive adenocarcinoma, IAC, n=42）即随着早期肺癌的演进过程不断增高。Ki-67 与各标志物的相关系数为0.386
（p53, P<0.001）、0.227(EGFR, P=0.024)、0.441（CEA, P<0.001）。通过ROC 曲线分析得到ki-67 来判别良恶性GGO 的曲线下面积
和最佳阈值，也得到了早期肺癌演进过程中ki-67 阈值变化。恶性GGO 组全血细胞中平均单核细胞含量低于良性组GGO，且差
异有统计学意义。结论：ki-67 表达量在不同病理类别的GGO中有显著性差异，且在肺癌演进过程中依次增高，可作为鉴别早期
肺癌不同病理类型的参考依据和预后因子；ki-67 与P53、EGFR 及CEA的表达具有一定的相关性。 |
| 英文摘要: |
| Objective:To explore the expression of ki-67 in the GGO of different pathology and try to find whether the correlation
of ki-67 with P53, EGFR and CEA.Methods:The clinical history, CT information, white blood cell count and pathology material of 254
cases with GGO during 2012 and 2014 were collected and analyzed retrospectively.Results:The expression level of ki-67 was gradually
increased fromBenign group (n=66), AAH (n=27), AIS (n=11), MIA (n=108), to IAC (n=42) , which is exactly the evolution progression
of early lung adenocarcinoma; The correlation coefficient were 0.386 (p53, P<0.001), 0.227(EGFR, P=0.024) and 0.441 (CEA, P<0.001)
respectively; By ROC curve analysis, we got the AUC and optimal cut-off points of ki-67 with regarding to differentiation of GGO and
the variation of thresholds along the progression of early lung adenocarcinoma; The number and the percentage of blood monocyte of the
patients with malignant GGO were lower than these of benign group.Conclusion:There are significant differences among GGOs of
different pathologic categories with respect to the expression of ki-67 that gradually increased in the early lung adenocarcinoma
progression. To some extent, a positive correlation of ki-67 with P53, EGFR and CEA exists. |
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