| 杨璐 华宇威 寇俊萍 余伯阳.组织因子与代谢性综合征的研究进展[J].,2015,15(31):6175-6178 |
| 组织因子与代谢性综合征的研究进展 |
| Advances on the Study of the Tissue Factor and Metabolic Syndrome |
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| DOI： |
| 中文关键词: 组织因子 代谢性综合征 代谢性综合征临床症候群 胰岛素抵抗 |
| 英文关键词: Tissue factor Metabolic syndrome Clinical symptomcomplex of MS Insulin resistance |
| 基金项目:中央高校基本科研业务费专项资金重点项目（JKZ2009010）；江苏高校优势学科建设工程资助项目 |
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| 中文摘要: |
| 组织因子（Tissue factor, TF）又称凝血因子III，是凝血因子VII/VIIa 细胞表面的受体和辅因子，为外源性凝血的启动因子，在
生理性止血、病理性血栓形成等发挥重要作用。近年临床研究发现，TF 在代谢性综合征（Metabolic syndrome, MS）患者体内活性
水平明显升高，并且与胰岛素抵抗、2 型糖尿病、中心性肥胖、高血压、血脂紊乱等MS多种临床症候群密切相关。本文就近年国外
相关进展作一综述，以期为针对TF这一作用靶点的MS 病情演变预测及药物开发提供参考依据。 |
| 英文摘要: |
| Tissue factor (TF), also named factor III, is a receptor and cofactor on the cell surface of factor VII/VIIa. As an initiator
of the extrinsic coagulation cascade, TF plays an important role in physiological hemostasis and pathological thrombosis etc. Recent
clinical studies have revealed that elevated levels of TF are observed in patients with metabolic syndrome (MS), and the increase is significantly
associated with clinical symptom complex of MS, such as insulin resistance, diabetes mellitus, central obesity, hypertension
and dyslipidemia. In this review, we summarize the latest abroad research of the role of TF in MS, so as to provide related information for
progression prediction and the drug development of MS by targeting TF. |
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