| 畅文丽 应泽华 曾春红 谢燕斌 张小虎.糖皮质激素联合玻璃酸钠关节腔内注射治疗膝关节骨性关节炎的临床研究[J].,2015,15(31):6122-6124 |
| 糖皮质激素联合玻璃酸钠关节腔内注射治疗膝关节骨性关节炎的临床研究 |
| Glucocorticoid Combined with Intra-articular Injection of SodiumHyaluronate for Knee Osteoarthritis |
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| DOI： |
| 中文关键词: 糖皮质激素 玻璃酸钠 关节腔内注射 膝关节骨性关节炎 |
| 英文关键词: Glucocorticoid Sodiumhyaluronate Intra-articular injection Knee osteoarthritis |
| 基金项目: |
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| 中文摘要: |
| 目的：探究糖皮质激素联合玻璃酸钠关节腔内注射治疗膝关节骨性关节炎的临床疗效。方法：选取2012 年6 月至2014 年6
月期间我院接收的120 例患有膝关节骨性关节炎的患者，并按照随机数字数表法分为观察组和对照组，每组60 例，均给予膝关
节腔内注射2.5 mL玻璃酸钠，在治疗第一周给予观察组患者膝关节腔内注射1 mL 复方倍他米松，对照组给予相同剂量的注射
用水；分别对治疗前、治疗后1 周、2 周、1 个月、3 个月、5个月时患者膝关节Lequence 评分，并对比两组治疗效果。结果：治疗后，
两组膝关节Lequence 评分均显著低于治疗前，且观察组降低更明显，差异均有统计学意义（P<0.05）；观察组患者治疗后1 周、2
周、1个月、3个月、5个月总有效率均高于对照组，且差异具有统计学意义（P<0.05）。结论：糖皮质激素联合玻璃酸钠关节腔内注
射治疗膝关节骨性关节炎具有良好的临床疗效，为临床治疗提供了新的思路。 |
| 英文摘要: |
| Objective:To explore the clinical curative effect of the glucocorticoid combined with intra-articular injection of sodium
hyaluronate in treatment of knee osteoarthritis.Methods:A total of 120 patients with knee osteoarthritis, who were treated in Mianyang
Central Hospital of Sichuan Province from June 2012 to June 2014, were randomly divided into observation group (n=60) and
control group (n=60). All the patients were given the injection of 2.5 mL sodium hyaluronate into the knee joint cavity once a week for 5
weeks. In the first week of treatment, the observation group was injected 1 mL compound betamethasone into the knee joint cavity, while
the control group, the same dose of injection water into the knee joint cavity. The knee joint Lequence scores and total effective rates of
the two groups were compared.Results:After treatment, Lequence scores of the knee joint of the two groups were significantly lower
than before treatment, and the observation group decreased more significantly, the difference was statistically significant (P<0.05). The
total effective rates of 1 week, 2 weeks, 1 month, 3 months, 5 months after treatment in the observation group were higher than those in
the control group, the differences were statistically significant (P<0.05).Conclusion:The glucocorticoid combined with intra-articular injection
of sodium hyaluronate in the treatment of knee osteoarthritis has a good clinical effect,which provides a new thinking for clinical
treatment. |
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