| 符娟 吴彪 林锋 邓伟 钟有清.复合型抗菌药联合阿奇霉素对大叶性肺炎炎性指标的影响[J].,2015,15(31):6082-6085 |
| 复合型抗菌药联合阿奇霉素对大叶性肺炎炎性指标的影响 |
| Effects of Compound Antimicrobial Agents on the Inflammatory Factorsof Lobar Pneumonia |
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| DOI： |
| 中文关键词: 阿奇霉素 大叶性肺炎 TNF-alpha IL-6 HMGB1 |
| 英文关键词: Azithromycin Lobar pneumonia TNF-alpha IL-6 HMGB1 |
| 基金项目:国家自然科学基金项目（81360172) |
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| 中文摘要: |
| 目的：头孢哌酮钠舒巴坦钠与阿奇霉素联合应用对大叶性肺炎病人体内TNF-alpha、IL-6 及HMGB1 的变化影响及其临床疗效
研究。方法：收集2012 年11 月至2015 年3 月期间到笔者所在医院就诊并诊断患有大叶性肺炎的病人随机平分成两组，其中A
组与B组成员分别使用头孢哌酮钠舒巴坦钠+阿奇霉素和仅使用阿奇霉素进行大叶性肺炎对症治疗。通过炎性指标变化情况及
对肺功能、不良反应的观察，分析两种药物联合应用对大叶性肺炎病人体内TNF-alpha、IL-6 及HMGB1 的变化影响和临床应用价
值。结果：A 组经联合用药治疗后相关炎症指标改善情况普遍优于B 组；A 组大叶性肺炎病人咳嗽、啰音及相关体征表现恢复速
度快于B 组，且A 组病人在联合药物治疗后FEF 和FEF50 指标上的改善情况更为突出；而A组病人不良反应发生种类及例数、
比率与B 组却相差不大（P>0.05）。结论：头孢哌酮钠舒巴坦钠与阿奇霉素的联合应用可有效降低病人体内TNF-alpha、IL-6 及
HMGB1 浓度水平，且其治疗效果较为突出，具有一定的应用价值。 |
| 英文摘要: |
| Objective:To investigate the effect of lobar pneumonia patients's TNF-alpha, IL-6 and HMGB1 by Cefoperazone sulbactamcombined
with azithromycin.Methods:The patents diagnosed as lobar pneumonia on November 2012 to March 2015 were randomly
divided into two groups, The members of Group A were treated with cefoperazone sulbactam + azithromycin and group B were only using
azithromycin for treatment. By observing the changes in the indicators, analysis of the two drugs combined application of lobar pneumonia
patient TNF -alpha, IL-6, HMGB1 and to explore the clinical application value.Results:Group A after combination therapy in the
treatment of inflammatory markers improvement is generally superior to that in group B; group a lobar pneumonia cough, rales and signs
performance recovery is faster than that of group B and combination drug therapy after FEF and fef50 index in the patients of a group to
improve the situation more (the part not over) is one of the most outstanding; and group A patients with adverse reactions occurred types
and case number, ratio of a and B differ little (P>0.05).Conclusion:Cefoperazone sulbactam in combination with azithromycin can reduce
expression levels of TNF-alpha, IL-6 and HMGB1 and its treatment effect is more prominent, it has some clinical value. |
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