| 郭连英 娜日格乐 关兴芳 王雪 李传刚 舒晓宏 李墨林.PADs介导的瓜氨酸化与肿瘤关系的研究进展[J].,2015,15(30):5977-5981 |
| PADs介导的瓜氨酸化与肿瘤关系的研究进展 |
| Research Progress on Correlation of PAD-mediated Citrullination withMalignant Tumors |
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| DOI： |
| 中文关键词: 蛋白质精氨酸脱亚胺酶 瓜氨酸化 靶蛋白 肿瘤 |
| 英文关键词: PADs Citrullination Target proteins Tumors |
| 基金项目:国家自然科学基金项目（81072063）；大连市科技计划项目基金项目（2012E15SF159）；
辽宁省教育科学"十二五" 规划2014 年度立项课题（JG14DB119） |
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| 中文摘要: |
| 瓜氨酸化(citrullination)是指在蛋白质精氨酸脱亚胺酶(peptidylarginine deiminases，PADs)作用下蛋白质肽链中的精氨酸残基
转化为瓜氨酸残基的过程，是一种重要的蛋白质翻译后修饰的过程。目前，已有5 种PAD 酶在人体组织中被发现，分别为
PAD1~4 和PAD6，PAD2 和PAD4 在许多恶性肿瘤组织中呈高表达。研究发现组蛋白、细胞角蛋白、纤维粘连蛋白、白介素8 等蛋
白质均可被瓜氨酸化，并与肿瘤细胞的增殖、分化、凋亡、迁移等密切相关。本文从表观遗传学观点出发就PADs 介导的蛋白质瓜
氨酸化与肿瘤关系的研究进展进行综述，为深入探讨肿瘤的发生发展机制及其治疗提供新的研究思路。 |
| 英文摘要: |
| Protein citrullination referred to the process that peptidylarginine deiminase (PAD) catalyses arginine residual to
citruline one. It was one of the most important post-translational modifications of proteins. Currently five mammalian PAD family
members had been discovered, in which PAD2 and PAD4 were demonstrated to be overexpressed in many types of malignant tumors. It
had been demonstrated that histone, cytokeratin, fibronectin and interleukin 8, et al could be citrullinated, and were closely correlated
with the proliferation, differentiation, apoptosis, invasion and metastasis of tumors. In view of epigenetic perspectives, the progress on the
relationship between PAD-mediated Citrullination and malignant tumors would be summarized in this review. |
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