| 孙莉 杨波 高艳霞 孙亚楠 梁磊.SSTR-2、E-cad与不明原因的反复自然流产相关性研究[J].,2015,15(30):5932-5934 |
| SSTR-2、E-cad与不明原因的反复自然流产相关性研究 |
| Correlation between SSTR-2, E-cad and UnexplainedRecurrent Spontaneous Abortion |
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| DOI： |
| 中文关键词: 生长抑素2 型受体 E- 钙粘附素 反复自然流产 |
| 英文关键词: SSTR-2 E-cad Recurrent spontaneous abortion |
| 基金项目:河北省计生委科研课题（2011-A21） |
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| 中文摘要: |
| 目的：研究生长抑素2 型受体(SSTR2)、E- 钙粘附素（E-cad）与不明原因的反复自然流产相关性。方法：选取2011 年1 月到
2014 年12 月我院收治的不明原因反复自然流产患者60 例（研究组），另选同期早期正常孕妇且准备流产者60 例（对照组），应用
免疫组化技术检测两组蜕膜组织中的SSTR2 和E-cad 表达，并进行比较。结果：研究组蜕膜组织中SSTR-2 阳性细胞平均光密度
显著高于对照组，而E-cad 阳性细胞平均光密度显著低于对照组，两组比较差异具有统计学意义（P＜0.05）；研究组蜕膜组织中
SSTR-2 与E-cad 水平呈负相关关系，对照组蜕膜组织中SSTR-2 与E-cad 水平呈正相关关系（P＜0.05）。结论：蜕膜组织中
SSTR-2 高表达与E-cad 低表达可能与不明原因的反复自然流产有关。 |
| 英文摘要: |
| Objective:To study the correlation between somatostatin receptor type 2 (SSTR-2), E-cadherin (E-cad) and
unexplained recurrent spontaneous abortion.Methods:Selected 60 patients with unexplained recurrent spontaneous abortion from our
hospital from January 2011 to December 2014 (as study group), and another 60 early normal pregnant who prepared to abort from the
same period (as control group), then detected and compared the expression level of SSTR2 and E-cad in deciduas of two groups by
immunohistochemistry method.Results:SSTR-2 positive cell mean optical density in study group was significantly higher than control
group, but the E-cad positive cell mean optical density was significantly lower than control group, the differences were statistically
significant (P<0.05); Expression level of SSTR-2 was negatively correlated with E-cad in deciduas of study group, while the expression
level of SSTR-2 was positively correlated with and E-cad in deciduas of control group (P<0.05).Conclusion:High expression of SSTR-2
and Low expression of E-cad in deciduas may be correlated with unexplained recurrent spontaneous abortion. |
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