| 吴春风 曾建平 廖德祥 周贻 胡柯.早期NT-proBNP变化率对CRT 患者长期预后的评价[J].,2015,15(30):5921-5924 |
| 早期NT-proBNP变化率对CRT 患者长期预后的评价 |
| Long-termPrognostic Value of Short-termEvariation of Plasma NT-proBNPbefore and after CRT Treatment in Patients with Chronic Heart Failure |
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| DOI： |
| 中文关键词: N 末端脑钠肽前体 心脏再同步化治疗 预后 |
| 英文关键词: N-terminal pro-B-type natriureticpeptide Cardiac resynchronization therapy Prognosis |
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| 中文摘要: |
| 目的：探讨慢性心力衰竭患者心脏再同步化治疗(cardiac resynchronizationtherapy，CRT) 后早期血浆N 末端脑钠肽前体
（N-terminal pro-B-type natriureticpeptide，NT-proBNP）变化对患者长期预后评估的价值。方法：采取随机对照的方法，选取40例符
合行CRT 治疗的慢性心力衰竭患者，分别检测CRT 植入前、CRT 植入后14 d的血浆NT-proBNP 水平，并计算14 d内血浆
NT-proBNP 水平变化率（△NT-proBNP），根据14 d △NT-proBNP 结果分为A 组（△NT-proBNP＜30%）、B 组（△NT-proBNP≥
30%），观察CRT 植入术后1 年内患者的不良心脏事件发生率、病死率、再住院时间及1 年后纽约心功能（New York Heart
Association，NYHA）分级、左室射血分数(Left ventricular ejection fraction，LVEF)、左室舒张末内径(left ventricular end-diastolic
diameter，LVEDD)。结果：B 组患者1 年不良心脏事件发生率、病死率及左室舒张末内径(LVEDD)均低于A 组患者，再住院时间及
左室舒张末内径(LVEDD)明显短于A 组患者，而NYHA心功能分级、左室射血分数(LVEF)高于A 组患者(P<0.05)。结论：慢性心
力衰竭患者行CRT 后早期NT-proBNP水平变化可以评估患者病情的长期预后。 |
| 英文摘要: |
| Objective:To evaluate the long-term prognostic value of short-term evariation of plasma N-terminal pro-B-type
natriureticpeptide (NT-proBNP) after cardiac resynchronizationtherapy (CRT) treatment in patients with chronic heart failure.Methods:Plasma NT-proBNP levels were measured before CRT, 14days after CRT in 40 patients with chronic congestive heart failure. The
decreasing rate of plasma NT-proBNP levels (△NT-proBNP)within 14 days was also calculated.The patients were divided into two
groups:Agroup (△NT-proBNP＜30 %) and B group (△NT-proBNP≥ 30 %). The incidence of adverse cardiac events, mortality and
length of rehospitation were observed within one year after receiving CRT. New York Heart Association (NYHA) functional class, Left
ventricular ejection fraction(LVEF), Left ventricular end-diastolic dimension(LVEDD) were also measured one year after receiving CRT.Results:During the period of observation, the incidence of adverse cardiac events, mortality, length of rehospitalization and LVEDD in
group B within 1 year were lower than those of patients in group A (P＜0.05). Compared with group A, the NYHA functional class,
LVEF was higher in group B (P＜0.05).Conclusion:The short-term evariation of plasma NT-proBNP before and after CRT treatment
can predict the long-termeffect of CRT in patients with chronic heart failure. |
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