| 何旺 贾真 张渭涛 郝姝 施秉银.免疫诱导对胰岛素抵抗患者干燥综合征的影响[J].,2015,15(29):5735-5737 |
| 免疫诱导对胰岛素抵抗患者干燥综合征的影响 |
| The Influence Research of Inducing Immune Reaction of the Patients withInsulin Resistance to Sicca Syndrome |
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| DOI： |
| 中文关键词: 胰岛素抵抗 自身免疫反应 干燥综合症 发生率 |
| 英文关键词: Insulin resistance Autoimmunity Sjogren's syndrome Incidence |
| 基金项目:国家自然科学基金项目(81173211) |
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| 中文摘要: |
| 目的：分析免疫诱导治疗胰岛素抵抗合并干燥综合症的临床效果。方法：选取2013 年1 月到2014 年12 月内在我院接受治
疗的156 例胰岛素抵抗合并干燥综合症患者并随机分为对照组和研究组，对照组患者采用药物治疗，研究组患者在对照组患者
基础上诱导其发生自身免疫反应治疗，分别对两组患者治疗后检测两组患者的FT3、FT4、TSH、血清IL-21 水平并统计干燥综合
症的治愈例数。结果：研究组患者的FT3、FT4以及血清IL-21 水平明显高于对照组，TSH显著低于对照组，差异均具有统计学意
义（P＜0.05）；研究组干燥综合症的治愈率为53.85 %，显著高于对照组的34.62 %，差异具有统计学意义（P＜0.05）。结论：免疫诱
导治疗胰岛素抵抗合并干燥综合症能够获得较好的治疗效果。 |
| 英文摘要: |
| Objective:To analyze the influence of inducing immune reaction of the patients with insulin resistance to sicca syndrome.Methods:156 cases of patients with insulin resistance and sjoegren syndrome in our hospital from January 2013 to December
2014 randomly were divided into control group and study group, the control group was treated with drug therapy, and the study group
was treated with inducing immune reaction based on the control group. The level of FT3, FT4, TSH and serum IL-21 for all the patients
was detected after treatment. The number of cured cases of Sjogren's syndrome was statistically analyzed.Results:The level of FT3, FT4
and serum IL-21 in study group were significantly higher than those in the control group, and TSH was lower than that of the control
group significantly, P<0.05. The cure rate of sicca syndrome of the study group was significantly higher than that of the control group,
P<0.05.Conclusion:It can get better treatment effect by immune induced insulin resistance combined with dry syndrome. |
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