| 杨蒙 吴宏志 邵洪波 冯建科 魏伟 孟令敏 张庆富.鼠神经生长因子对电烧伤患者神经修复的作用及其机制研究[J].,2015,15(29):5708-5712 |
| 鼠神经生长因子对电烧伤患者神经修复的作用及其机制研究 |
| Effect and Mechanismof Mouse Nerve Growth Factor on Nerve Repair inPatients with Electrical Burns |
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| DOI： |
| 中文关键词: 鼠神经生长因子 电烧伤 神经修复 运动 感觉 功能 |
| 英文关键词: Mouse nerve growth factor Electrical burns Nerve repair Motor Sensory Function |
| 基金项目:河北省卫生厅科研项目（20130273） |
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| 中文摘要: |
| 目的：探讨鼠神经生长因子对电烧伤患者神经修复的作用及其机制。方法：选取2013 年2 月至2014 年11 月期间我院确诊
治疗的四肢电烧伤患者128 例，依据随机分配原则分为对照组和神经组，对照组患者给予常规皮瓣修复术治疗，神经组患者在此
基础上给予鼠神经生长因子治疗，且依据给药方式分为全身亚组和局部亚组。统计分析所有患者创面愈合时间、感染和出血发生
情况，采用BMRC 感觉、运动功能评级法评估患者感觉、运动功能恢复情况，应用Spearman 分析法分析二者之间的关系。结果：神
经组患者创面愈合时间、感染和出血发生率明显低于对照组，差异有统计学意义（P<0.05）；局部亚组患者感觉功能优良率为
90.63%，全身亚组为84.38%，对照组为71.88%，局部亚组> 全身亚组> 对照组，差异有统计学意义（P<0.05）；局部亚组患者运动
功能优良率为93.75%，全身亚组为84.38%，对照组为76.56%，局部亚组>全身亚组>对照组，差异有统计学意义（P<0.05）；
Spearman 分析法结果显示，感觉功能与运动功能呈正相关（r=0.812，P<0.05）。结论：鼠神经生长因子可有效提高电烧伤患者神经
修复的作用，有利于改善患者术后创面愈合、感染、出血情况，促进患者感觉、运动功能恢复，且通过局部给药方式具有更为良好
的神经修复作用，值得临床作进一步推广。 |
| 英文摘要: |
| Objective:To explore the effect and mechanism of mouse nerve growth factor on nerve repair in patients with electrical
burns.Methods:Selected 128 patients with limbs electrical burns who were treated in our hospital from February 2013 to November
2014, they were divided into control group and nerve group according to the random number table method, control group was treated
with routine skin flap repair, while nerve group was treated with mouse nerve growth factor on the basis of the therapy of control group,
which was divided into general group and local group according to the drug delivery way. Then analyzed the wound healing time and the
incidence of wound infection and hemorrhage of all patients, evaluated the status of sensory and motor function recovery by BMRC sensory
and motor function rating methods, adopted Spearman analysismethod to analyze the relationship between sensory and motor function.Results:Wound healing time, incidence of wound infection and hemorrhage in nerve group were lower than control group, the differences
were statistically significant (P<0.05); Excellent and good rate of sensory function in local group was 90.63%, general group was
84.38%, control group was 71.88%, this rate descending order was local group>general group>control group (P<0.05); Excellent and
good rate of motor function in local group was 93.75%, general group was 84.38%, control group was 76.56%, and the descending order
was local group>general group>control group(P<0.05); Spearman analysis showed, sensory function was positively correlated with motor
function (r=0.812, P<0.05).Conclusion:Mouse nerve growth factor can effectively improve the nerve repair in patients with electrical
burns, which is good for the wound healing, reducing wound infection and hemorrhage, promoting sensory and motor function recovery,
furthermore, the local drug delivery method has better nerve repair effect, it's worth for further clinical promotion. |
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