| 张渭涛 施秉银 何旺 贾真 郝姝.吡格列酮和二甲双胍对初诊2 型糖尿病患者肠源性内毒素水平的影响[J].,2015,15(29):5648-5650 |
| 吡格列酮和二甲双胍对初诊2 型糖尿病患者肠源性内毒素水平的影响 |
| A Study on the Effect of Pioglitazone and Metformin on IntestinalEndotoxemia Levels in Patients with Newly Diagnosed Type 2 Diabetes |
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| DOI： |
| 中文关键词: 吡格列酮 二甲双胍 肠源性内毒素 2 型糖尿病 |
| 英文关键词: Pioglitazone Metformin Gut-derived endotoxin Type 2 diabetes |
| 基金项目:国家自然科学基金项目(81070471) |
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| 中文摘要: |
| 目的：探究吡格列酮和二甲双胍对初诊2 型糖尿病患者肠源性内毒素水平的影响。方法：选取初诊2 型糖尿病患者105例，
随机分为吡格列酮治疗组(52 例)和二甲双胍治疗组(53 例)，以同期性别、年龄匹配的健康体检者42 例作为对照组，治疗12 周之
后比较两组治疗前后肠源性内毒素及相关生化指标的变化情况。结果：治疗前，两治疗组的肠源性内毒素水平均显著高于对照组
(P<0.05)；吡格列酮治疗后，患者肠源性内毒素和hs-CRP 水平均下降较为明显(P<0.01)；而二甲双胍治疗后，仅hs-CRP 水平显著
下降，差异具有统计学意义(P<0.05)，而肠源性内毒素下降不明显(P>0.05)；但两种药物治疗后，肠源性内毒素水平仍高于对照组
(P<0.01)。结论：吡格列酮可以降低初诊2 型糖尿病患者的肠源性内毒素水平，而二甲双胍对肠源性内毒素的下降作用不明显。 |
| 英文摘要: |
| Objective:To study the effect of pioglitazone and metformin on intestinal endotoxemia levels in patients with newly
diagnosed type 2 diabetes.Methods:105 patients with newly diagnosed type 2 diabetic were randomly divided into the pioglitazone treatment
group (52 cases) and metformin treatment group (53 cases), 42 sex, age-matched healthy people were selected as Control in the
same period. The changes of intestinal endotoxemia and biochemical parameters levels after 12 weeks' treatment were compared.Results:The intestinal endotoxemia lever were higher in both pioglitazone and metformin treatment groups before treatment than that of the control
group(P<0.05). When pioglitazone was used, toxins, hs-CRP levels in the intestinal were decreased more significantly (P<0.01), only
hs-CRP decrease was statistically significant when metformin used (P<0.05), no significant decline in intestinal endotoxemi. Toxin level
was still higher than those in the intestinal after the 2 drugs treatment (P<0.01).Conclusion:Pioglitazone could reduce the intestinal endotoxemia
level of patients with newly diagnosed type 2 diabetes, while metformin hadn't obvious effect on the intestinal endotoxemia
level. |
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