| Objective:To study the effects of total flavonoids of Glycyrrhiza on the expression of COX-1 and COX-2 in the gastric
mucosa of patients with chronic superficial gastritis.Methods:48 cases patients with superficial gastritis of chronic phase were selected
in our hospital from January 2014 to December 2014, were randomly divided into two groups, 24 patients in control group received
conventional drugs, amoxicillin 0.5 g/time, 3 times /d, oral; 24 cases in the experimental group, be licorice flavonoids extract capsules 10
g/ times, 3 /d, oral, 7 d for a course of treatment, a total of two courses of treatment. During the treatment, avoiding alcohol, light diet was
required. After the end of treatment, the clinical curative effect and the apoptosis of gastric mucosal cell was detected and the positive
rate of COX-1 and COX-2 was detected.Results:After the treatment, the positive rate of COX-1 in the experimental group and the
control group were significantly increased with significant difference (t=2.489, P=0.021), (t=2.115, P=0.017); compared with the control
group, it was increased more significantly in the experimental group with significant difference (t=0.033, P=2.739), after treatment, the
COX-2 positive rate was significantly decreased in two groups with significant difference (t=1.937, P=0.014), (t=2.603, P=0.025);
compared with the control group, the positive rate of the experimental group was decreased more obviously, and the difference had
statistical significance (t=2.316, P=0.019); after treatment, the apoptotic index of the gastric mucosa of two groups were significantly
decreased with significant difference (P<0.05), compared with control group, the apoptosis index was decreased more significantly in the
experimental group with significant difference (P<0.05). Compared with control group，effective rate of the experimental group was
higher，(P<0.05).Conclusion:The total flavonoids of glycyrrhiza uralensis can significantly improve the clinical symptoms caused by
chronic superficial gastritis caused, can increase the level of COX-1, and decrease the level of COX-2, it is worth promotion and
application in clinic. |
