| 柯珂 余云熹 余竹金 张斌 王晓琴.弥漫性大B 细胞淋巴瘤hs-CRP和VEGF的表达及与化疗耐药的相关性[J].,2015,15(26):5150-5152 |
| 弥漫性大B 细胞淋巴瘤hs-CRP和VEGF的表达及与化疗耐药的相关性 |
| Relationship between Expression of hs-CRP and VEGF in Diffuse LargeB-cell Lymphoma and Chemotherapy Resistance |
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| DOI： |
| 中文关键词: 弥漫性大B 细胞淋巴瘤 超敏C-反应蛋白 血管内皮生长因子 |
| 英文关键词: Diffuse large B-cell lymphoma hs-CRP VEGF |
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| 中文摘要: |
| 目的：研究弥漫性大B 细胞淋巴瘤超敏C- 反应蛋白（hs-CRP）和血管内皮生长因子（VEGF）的表达及与化疗耐药的相关性。
方法：选取2013 年11 月到2014 年11 月我院收治的化疗耐药弥漫性大B 细胞淋巴瘤25 例（A 组），化疗敏感弥漫性大B 细胞淋
巴瘤25 例（B组），另选取同期健康者25 例（C 组）。应用免疫荧光法检测三组入选者的hs-CRP,及酶联免疫吸附法试验（ELISA）
法检测VEGF。结果：化疗前A 组hs-CRP、VEGF水平显著高于B 组和C 组，B 组高于C 组，比较差异具有统计学意义（P＜ 0.05）；
化疗缓解后A组和B组hs-CRP、VEGF水平与化疗前比显著降低，差异有统计学意义（P＜0.05），但两组间比较差异无统计学意
义（P＞0.05）；A组复发耐药后hs-CRP、VEGF 水平与缓解后比显著升高，差异具有统计学意义（P＜0.05）。结论：弥漫性大B细胞
淋巴瘤血清中hs-CRP、VEGF水平改变与病情变化有关，可能与化疗耐药有关。 |
| 英文摘要: |
| Objective:To study the relationship between expression levels of hs-CRP and vas- cular endothelial growth factor
(VEGF) in diffuse large B-cell lymphoma and chemotherapy resistance.Methods:A total of 25 cases of diffuse large B-cell lymphoma
with chemotherapy resistance were selected as group A; 25 cases of diffuse large B-cell lymphoma with chemotherapy sensitivity were
selected as group B; 25 healthy people in the same period, who were all admitted to Huangshi Central Hospital from November 2013 to
November 2014 were selected as group C. The hs-CRP levels of three groups were detected by immunofluorescence, and the levels of
VEGF, were detected by enzyme-linked immunosorbent assay test (ELISA).Results:The levels of hs-CRP and VEGF in group A were
significantly higher than those in group B and group C, those in group B were higher than those in group C before chemotherapy, the differences
were statistically significant (P<0.05). Compared to before chemotherapy, the levels of hs-CRP and VEGF in group A and group
B significantly decreased after chemotherapy remission, the differences were statistically significant (P<0.05), but the difference between
the two groups was not statistically significant (P>0.05). Compared to after chemotherapy remission, the levels of hs-CRP and VEGF in
group A significantly increased after recurrence of resistance, the differences were statistically significant (P<0.05).Conclusion:The
change of hs-CRP and VEGF levels in diffuse large B-cell lymphoma is related to the patients' condition changes, which may be associated
with chemotherapy resistance. |
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