| 张晓峰 李凤霜 范晓芬 王卉 袁赟.小剂量顺铂动脉化疗联合放疗对中晚期宫颈癌的临床疗效[J].,2015,15(23):4505-4508 |
| 小剂量顺铂动脉化疗联合放疗对中晚期宫颈癌的临床疗效 |
| Different Doses of Cisplatin for Arterial Chemotherapy Combined withRadiotherapy in Advanced Cervical Cancer |
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| DOI： |
| 中文关键词: 动脉化疗 中晚期宫颈癌 小剂量顺铂 放疗 |
| 英文关键词: Arterial chemotherapy Advanced cervical cancer Lowdose cisplatin Radiotherapy |
| 基金项目:国家自然科学基金项目（30672254） |
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| 中文摘要: |
| 目的：探讨小剂量顺铂用于子宫动脉化疗联合放疗治疗中晚期宫颈癌的临床疗效。方法：选择2010 年8 月~2012 年8 月我
院收治的中晚期宫颈癌患者75 例，根据不同治疗方案将其分为单纯放疗组25 例（单纯采用放疗治疗）、小剂量动脉化疗组25 例
（同时放化疗，顺铂周疗的剂量控制在20 mg·m-2）及标准剂量静脉化疗组25 例（同时放化疗，顺铂周疗的剂量控制在40 mg·m-2）。
观察并比较三组患者的临床疗效、两年生存率及毒性反应发生情况等。结果：小剂量动脉化疗组与标准剂量静脉化疗组的总有效
率及两年生存率显著高于单纯放疗组（P<0.05），小剂量动脉化疗组的总有效率和两年生存率高于标准剂量静脉组，差异具有统计
学意义（P<0.05）。单纯放疗组及小剂量动脉化疗组的毒性反应发生率显著低于标准剂量静脉组（P<0.05）；单纯放疗组与小剂量动
脉化疗组患者的毒性反应发生率对比无统计学差异（P>0.05）。结论：小剂量顺铂动脉化疗可以有效降低中晚期宫颈癌患者的急性
毒性反应，值得临床进一步推广应用。 |
| 英文摘要: |
| Objective:To investigate the clinical efficacy of low-dosed cisplatin in chemotherapy and radiotherapy on the
treatment of the advanced cervical cancer.Methods:75 patients with advanced cervical cancer who were treated in our hospital from
August 2010 to 2012 were selected. According to the different treatment methods, the patients were divided into the radiotherapy group
(25 cases who were treated with radiotherapy), the low-dosed group (25 cases who were treated with 20 mg·m-2 cisplatin in
chemotherapy and radiotherapy) and the standard-dosed group (25 cases who were treated with 40 mg·m-2 cisplatin in chemotherapy and
radiotherapy). Then the toxic reaction, clinical effect and the two-years’survival rate in the three groups were observed and compared.Results:The total effective rate and survival rate of the low-dosed group and the standard-dosed group were significantly higher than
those of the radiotherapy group (P<0.05); The curative effect rate and the survival rate of low-dosed group were higher than those of the
standard-dosed group, and the differences were statistically significant (P<0.05). The toxicity reaction of the radiotherapy group and the
low-dosed group were significantly lower than that of the standard-dosed group (P<0.05); There was no statistically significant about the
toxicity reaction between the radiotherapy group and the low-dosed group (P>0.05).Conclusion:Low dose cisplatin can reduce the
toxicity reactions of patients with advanced cervical cancer, and improve the curative effect and survival rate, which is worthy of clinical
application. |
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