| 李晟 蔡琳 张润岐 张楠 周伊 徐玉乔.胃癌中Fascin 表达与K-ras 突变情况及两者相关性的研究[J].,2015,15(21):4014-4016 |
| 胃癌中Fascin 表达与K-ras 突变情况及两者相关性的研究 |
| The Correlation between Expression of Fascin and Mutation of K-ras inGastric Cancer Tissue |
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| DOI： |
| 中文关键词: 胃癌 K-ras Fascin 免疫组织化学 DNA测序 |
| 英文关键词: Gastric cancer K-ras Fascin Immunohistochemical method DNA sequencing |
| 基金项目:国家自然科学基金青年项目（31400722）；陕西省教育厅科研计划项目（11JK0714）；西安医学院校级科研基金扶植项目（11FZ03） |
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| 中文摘要: |
| 目的：观察胃癌组织中Fascin 表达和K-ras 突变情况，并分析其与临床病理特征的关系，研究Fascin表达和K-ras突变之间
的相关性，探讨两者在胃癌浸润转移过程中的作用。方法：在108 例胃癌组织中采用免疫组织化学法检测Fascin 表达，采用DNA
测序法检测K-ras突变。结果：108 例胃癌组织中Fascin 表达率为25.00 %，K-ras突变率为11.11 %；胃癌组织中Fascin 阳性表达，
发生淋巴结转移组多于未发生淋巴结转移组(P＜0.05)，发生远处转移组多于未发生远处转移组（P＜0.01）；K-ras 突变，发生远处
转移组多于未发生远处转移组（P＜0.01）；胃癌组织中K-ras 突变和Fascin 表达之间存在相关性，Fascin阳性比Fascin阴性的胃癌
组织更倾向于发生K-ras突变（rp=0.378，P＜0.01）。结论：在胃癌组织中K-ras 基因突变和Fascin蛋白阳性表达存在相关性，且与
肿瘤的转移有关。 |
| 英文摘要: |
| Objective:To observe mutation of K-ras and expression of Fascin in gastric tissues and their relationship with clinical
pathological features, then to analyze the correlation between mutation of K-ras and expression of Fascin.Methods:In 108 cases of
gastric cancer tissues K-ras mutation was detected by DNA sequencing，Fascin expression was detected by immunohistochemical
method.Results:In gastric tissues the mutation rate of K-ras was 11.11 %, the expression rate of Fascin was 25.00 %; The mutation rate
of K-ras in distant metastasis group was higher than without distant metastasis group（P＜0.01）; The expression rate of Fascin in lymph
node metastasis group was higher than without lymph node metastasis group （P＜0.05）, and the expression rate of Fascin in distant
metastasis group was higher than without distant metastasis group（P＜0.01）; There was a correlation between the mutation of K-ras and
the expression of Fascin in gastric tissues, Fascin positive gastric cancer tissue are more inclined to K-ras mutation than Fascin negative
gastric cancer tissue (rp = 0.378, P<0.01).Conclusion:In gastric tissues there is a correlation between the mutation of K-ras and the
expression of Fascin. Both of themplay an important role in the process of invasion and metastasis. |
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