| 王玉峰 张赐童 罗雯静 梁先烈 王晓容.细胞对机械刺激感知的生物力学机制[J].,2015,15(20):3979-3981 |
| 细胞对机械刺激感知的生物力学机制 |
| Biomechanical Mechanismfor Cells to Perceive Mechanical Stimuli |
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| DOI： |
| 中文关键词: 整合素 G 蛋白耦联受体 张力活化通道 细胞核 |
| 英文关键词: Integrin G protein-coupled receptors SAC Nucleus |
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| 中文摘要: |
| 细胞作为机体的基本单位，始终处于一个受力环境中。微环境中的细胞不仅受化学信号的影响，还受基质刚度、外界力载荷
及胞外基质(ECM）结构的调控，这些都能影响细胞分化、迁移、形态发生、增殖等方面的生物学反应。目前，部分学者致力于细胞
生物力学的应用和机制方面的探索，但对于细胞力学感知机理的认知仍无法形成一个完整的定论。本文将就整合素、G蛋白耦联
受体、张力活化通道(SAC)、细胞核等介导的细胞生物力学感知通路作一综述。 |
| 英文摘要: |
| Cells, as the basic unit of organism, are always in a force-bearing environment. Presenting in microenvironment,cells
are not only affected by chemical signal but also regulated by mechanical factors including the stiffness of substrate, the external force
load and extracellular cell matrix structure. All of these can influence cell differentiation, migration, morphogenesis, proliferation, and
many other biological reactions. Nowadays, some scholars commit themselves to exploring the application and the mechanisms of cell
biomechanics, but until now all the cognition about the mechanism of cell mechanics can not achieve a complete conclusion. In this
paper, the biomechanical mechanism for cells to perceive mechanical stimuli from mechanotransduction pathways mediated by integrin,
G protein-coupled receptors, stress activated channel and nucleus is discussed. |
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