| Cell signal transduction pathway JAK-STAT was a major pathway in the cell by the cytokine outward nucleus transfer
signal, which was involved in mediating the cell growth, proliferation and differentiation, inflammation, apoptosis. The STAT proteins
were the core elements of JAK-STAT pathway, and all STAT proteins expressed in the heart, changing the molecular structure of
proteins was able to adjust the biological activity of STAT. Currently, there were many reports about the roles of STAT1, STAT3 in heart
disease, ischemic heart disease, ischemia-reperfusion induced myocardial injury, cardiac hypertrophy, heart failure after myocardial
infarction and ischemic pre/post processing mediated cardioprotective effects, etc, were closely related to STAT proteins. This review
focuses on the research progress of the role of STAT proteins in the heart disease. |
