| 饶少锋 冯霞 游晶 段勇 范晶华 张茹薏.Th17/Treg细胞及其失衡在乙型肝炎致病机制中的作用[J].,2015,15(19):3773-3776 |
| Th17/Treg细胞及其失衡在乙型肝炎致病机制中的作用 |
| The Role of Th17/Treg Cells and the Imbalancein the Pathogenesis of Hepatitis B |
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| DOI： |
| 中文关键词: 辅助性Th17 细胞（Th17） 调节性T 细胞（Treg） 乙型肝炎 细胞因子 动态平衡 |
| 英文关键词: Th17 cells Treg cells Hepatitis B Cytokines Dynamic balance |
| 基金项目:云南省科技计划项目（2011WS0053，2011FZ121，2012WS0028） |
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| 中文摘要: |
| 我国是乙型肝炎病毒( HBV) 高感染率国家，乙型肝炎发病机制十分复杂,宿主免疫调节紊乱是导致不能有效清除病毒、病
情迁延不愈的重要原因，其中CD4+T 淋巴细胞发挥主要作用。最近，新发现的CD4+Ｔ 细胞的几种亚群为乙型肝炎致病机制的研
究提供了新思路。这些新的Ｔ 细胞亚群中，有一种被称为Th17 细胞，表达转录因子ROR-酌t，并分泌各种IL-17 因子参与免疫反
应。另一种为Treg细胞，表达转录因子FoxP3，主要分泌TGF-茁因子，当TGF-茁单独存在时，初始的效应Ｔ 细胞分化为Treg 细
胞。辅助性Th17 细胞（Th17）和调节性T 细胞（regulatory T cell, Treg）在分化发育、增殖及功能上有着密切的联系，并参与乙型肝
炎的致病过程，对乙型肝炎的发生、发展、及愈后有一定影响。最近的研究表明，Th17／Treg 的失调可能参与了乙型肝炎的异常免
疫反应，从而导致慢性炎症的形成和HBV的持续感染。本文就Th17 细胞和Treg细胞及其失衡在乙型肝炎致病机制中的作用予
以综述，为乙型肝炎的免疫学治疗提供理论基础。 |
| 英文摘要: |
| Our country is high-prevalence hepatitis B virus (HBV) country, the pathogenesis of hepatitis B is very complex, host
immune adjustment disorder is the main reason of causing ineffectively remove viruses and illness delayed healing, among CD4 + T
lymphocytes playing a major role. Recently, the newly discovered subsets of CD4 + T cell provide a new idea about the pathogenesis of
hepatitis B. Among these new T cell subsets, there is a subset known as Th17 cells, which express the transcription factor of ROR-酌t and
secrete many kinds of IL-17 factors involved in immune response. Another is Treg cells, which express the transcription factor of FoxP3
and can secrete TGF-茁factor. When TGF-茁is alone, the initial effect of T cell could differentiate into Treg cells. Th17 cells and Treg
cells have closely association between the differentiation proliferation and function. They are both involved in the pathogenic process of
hepatitis B, and play a role in the occurrence, development, prognosis of hepatitis B. Recently researches have shown that Th17/Treg
imbalance may be involved in abnormal immune response of hepatitis, resulted in chronic inflammation and persistent infection of
hepatitis B. This article briefly reviewed the role of Th17/Treg and their imbalance in the pathogenesis of hepatitis B, providing a
theoretical basis for the immunological treatment of hepatitis B. |
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