| 汤梦娟 李岩 肖蕊 赵延 赵静 詹科.利奈唑胺对肾功能不全G+感染患者血小板减少的相关性研究[J].,2015,15(19):3711-3713 |
| 利奈唑胺对肾功能不全G+感染患者血小板减少的相关性研究 |
| Correlation of Linezolid with Thrombocytopenia in Patientswith Renal Dysfunction |
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| DOI： |
| 中文关键词: 利奈唑胺 肾功能不全 血小板减少 |
| 英文关键词: Linezolid Renal dysfunction Thrombocytopenia |
| 基金项目:卫生部医药卫生科技发展研究中心课题基金项目（W2013GJ09） |
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| 中文摘要: |
| 目的：分析利奈唑胺对肾功能不全G+患者血小板减少的关系。方法：回顾性分析92 例应用利奈唑胺治疗的革兰阳性球菌
感染患者的临床资料，根据是否伴有肾功能不全分为肾功能不全组（33 例），正常组（59 例），检测用药前、用药后血小板计数，观
察停药后血小板计数恢复正常时间及不良反应发生情况。结果：肾功能不全组治疗后血小板计数显著低于治疗前及正常组（P<0.01)，正
常组治疗前、后血小板计数比较无统计学意义（P>0.05)；肾功能不全组血小板减少发生率高于正常组（P<0.05)；停药后正常组血小
板恢复正常时间短于肾功能不全组（P<0.01)；肾功能不全组血红蛋白下降率高于正常组（P<0.05)，其余不良反应发生率比较差异
无统计学意义（P>0.05)。结论：感染患者肾功能可影响利奈唑胺所致血小板减少发生率，肾功能不全患者在应用利奈唑胺时应定
期监测血小板计数。 |
| 英文摘要: |
| Objective:To analyze the relationship of renal dysfunction and linezolid-induced thrombocytopenia.Methods:A
retrospective analysis was performed on the clinical data of 92 cases of linezolid-treated patients with Gram-positive bacterial infections.
33 patients with renal dysfunction were designed into the renal dysfunction group, and 59 other patients were assigned as normal group.
Detected the platelet before and after treatment, and observe the time for platelet count recovering to normal after treatment and the
occurrence of adverse reactions.Results:After treatment, platelet count of renal dysfunction group was significantly lower than before
treatment and normal group (P<0.01). There was no statistical difference in platelet count between before and after treatment in the
normal group (P>0.05). In renal dysfunction group, the incidence of thrombocytopenia was higher than in the normal group(P<0.05).
After treatment, the normal group took shorter time to have the platelet recovered than the renal dysfunction group(P<0.01). Hemoglobin
decreased greater in renal dysfunction group than in the normal group (P<0.05). The other incidences of adverse reactions showed no
significant differences (P>0.05).Conclusion:The kidney function of infected patients can affect their linezolid-induced thrombocytopenia.
Patients with renal dysfunction should have regular monitor on platelet counts when taking linezolid. |
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